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Gene Review:

TULP2 - tubby like protein 2

Homo sapiens

Synonyms: CT65, Cancer/testis antigen 65, TUBL2, Tubby-like protein 2, Tubby-related protein 2

North, M.A. et al., Nishina, P.M. et al., Bell, C.G. et al.

Nishina, North, Ikeda, Yan, Naggert,

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Disease relevance of TULP2

1. TULP1 and TULP2, which are expressed in the retina, make excellent candidates for these ocular diseases as a mutation within the tub gene is known to lead to early progressive retinal degeneration [1].

High impact information on TULP2

We also report that TUB, TULP1, and TULP2 map to human chromosomes 11p15.4, 6p21.3, and 19q13.1, respectively [1].
TULP1 and TULP2 map within the minimal intervals identified for retinitis pigmentosa 14 on chromosome 6p21.3 and cone-rod dystrophy on chromosome 19q13 [1].
Plausible positional candidate genes include NR1H2 and TULP2 [2].

Other interactions of TULP2

Also, like TUB, it has a wider pattern of tissue expression than either TULP1 or TULP2 [3].

References

Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases. North, M.A., Naggert, J.K., Yan, Y., Noben-Trauth, K., Nishina, P.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
Genome-wide linkage analysis for severe obesity in french caucasians finds significant susceptibility locus on chromosome 19q. Bell, C.G., Benzinou, M., Siddiq, A., Lecoeur, C., Dina, C., Lemainque, A., Clément, K., Basdevant, A., Guy-Grand, B., Mein, C.A., Meyre, D., Froguel, P. Diabetes (2004) [Pubmed]
Molecular characterization of a novel tubby gene family member, TULP3, in mouse and humans. Nishina, P.M., North, M.A., Ikeda, A., Yan, Y., Naggert, J.K. Genomics (1998) [Pubmed]

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TULP2	Bos taurus
TULP2	Canis lupus familiaris
LOC718915	Macaca mulatta
Tulp2	Mus musculus
TULP2	Pan troglodytes
Tulp2	Rattus norvegicus

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