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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Lrrc15  -  leucine rich repeat containing 15

Mus musculus

Synonyms: 5430427N11Rik, LIB, Leucine-rich repeat-containing protein 15
 
 
 
 
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High impact information on Lrrc15

  • At 5 weeks after irradiation, the EDC mice had lower total thymocyte numbers (p < 0.05) and a higher proportion of CD4-CD8-thymocytes than either the PF or AD LIB mice (p < 0.05), which is consistent with findings using in utero models of ethanol exposure [1].
  • B cells were the most sensitive to the detrimental effects of ethanol and, as a percentage of total nucleated cells in the spleen, B cells were decreased in the EDC group, compared with both the PF and AD LIB groups (p < 0.05) [1].

References

  1. Chronic ethanol exposure alters leukocyte subsets in repopulating spleens, but does not alter negative selection in thymuses of sublethally irradiated mice. Livant, E.J., Welles, E.G., Ewald, S.J. Alcohol. Clin. Exp. Res. (1997) [Pubmed]
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