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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

LRRC15  -  leucine rich repeat containing 15

Homo sapiens

Synonyms: LIB, Leucine-rich repeat protein induced by beta-amyloid homolog, Leucine-rich repeat-containing protein 15, hLib
 
 
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High impact information on LRRC15

  • The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation [1].
  • Here, we used cDNA subtractive hybridization to identify an endogenous gene, LRRC15, which is specifically up-regulated after inducible expression of EWS-WT1(+KTS) in cancer cell lines, and is expressed within primary DSRCT cells [1].
  • A polymorphic dinucleotide repeat probe on chromosome 3p: LIB 44-36ca (D3S769) [2].
  • In this study, the carbohydrate portions of Dol-PP-OS were analysed: in JB and LIB, they range in size from Man2GlcNAc2 to Glc3Man9GlcNAc2, predominant components being Man5-7GlcNAc2 and Glc3Man7GlcNAc2 [3].
 

Analytical, diagnostic and therapeutic context of LRRC15

  • PANTHER/LIB is a collection of "books," each representing a protein family as a multiple sequence alignment, a Hidden Markov Model (HMM), and a family tree [4].
  • The immunoassay system is based on the transient retention of the specific LIB-MC2 monoclonal antibody anti-TCP as a biotinylated derivative using the streptavidin-biotin interaction [5].

References

  1. Identification of a DNA-binding site and transcriptional target for the EWS-WT1(+KTS) oncoprotein. Reynolds, P.A., Smolen, G.A., Palmer, R.E., Sgroi, D., Yajnik, V., Gerald, W.L., Haber, D.A. Genes Dev. (2003) [Pubmed]
  2. A polymorphic dinucleotide repeat probe on chromosome 3p: LIB 44-36ca (D3S769). Schmidt, L., Li, H., Wei, M.H., Lerman, M.I., Zbar, B., Tory, K. Hum. Mol. Genet. (1993) [Pubmed]
  3. Stored dolichyl pyrophosphoryl oligosaccharides in Batten disease. Hall, N.A., Thomas-Oates, J.E., Dell, A., Haltia, M., Lake, B.D., Patrick, A.D. Am. J. Med. Genet. (1992) [Pubmed]
  4. PANTHER: a library of protein families and subfamilies indexed by function. Thomas, P.D., Campbell, M.J., Kejariwal, A., Mi, H., Karlak, B., Daverman, R., Diemer, K., Muruganujan, A., Narechania, A. Genome Res. (2003) [Pubmed]
  5. Determination of 3,5,6-trichloro-2-pyridinol (TCP) in water by a continuous competitive immunoassay system based on the streptavidin-biotin interaction. Delgado, R.F., Fernández, R.J., Luque, d.e. .C.M. Analytical and bioanalytical chemistry. (2002) [Pubmed]
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