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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ZNF177  -  zinc finger protein 177

Homo sapiens

Synonyms: Zinc finger protein 177
 
 
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High impact information on ZNF177

  • Our laboratory previously identified a novel, alternatively spliced zinc-finger gene, ZNF177, which incorporates Alu L1, and HERV segments into the 5' untranslated region (UTR) of transcripts [1].
  • Our findings indicate that the Alu and L1 repeats in the 5' UTR of ZNF177 exert a positive transcriptional enhancer effect, but repress translation of the zinc finger gene [1].
  • In this study, we investigated the genomic structure and functional significance of the repetitive sequences in the 5' UTR of ZNF177 mRNAs [1].
 

Biological context of ZNF177

  • Characterization of the clones revealed that they represent transcripts from a novel KRAB zinc finger gene termed ZNF177 [2].
 

Analytical, diagnostic and therapeutic context of ZNF177

  • Northern and RT-PCR analyses suggest that ZNF177 is transcribed at a low level in a variety of cell types [2].
  • Genomic PCR and hybridization experiments suggest that a partial HERV-H element is integrated within the ZNF177 locus, which Southern analysis has shown to be a single-copy gene [2].

References

  1. Repetitive elements in the 5' untranslated region of a human zinc-finger gene modulate transcription and translation efficiency. Landry, J.R., Medstrand, P., Mager, D.L. Genomics (2001) [Pubmed]
  2. Transcripts from a novel human KRAB zinc finger gene contain spliced Alu and endogenous retroviral segments. Baban, S., Freeman, J.D., Mager, D.L. Genomics (1996) [Pubmed]
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