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Gene Review

Igsf3  -  immunoglobulin superfamily, member 3

Mus musculus

Synonyms: 1700016K10Rik, 2810035F16Rik, 4833439O17Rik, IgSF3, Immunoglobulin superfamily member 3, ...
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High impact information on Igsf3

  • Additional support for the candidacy of Cd101 is the presence of 17 exonic single-nucleotide polymorphisms that differ between the NOD and B6 sequences, 10 causing amino acid substitutions in the predicted CD101 protein [1].
  • Determined amino acid sequence analysis of the purified p126 polypeptide revealed that it is the protein product of the recently identified V7 gene, which has structural similarities to members of the Ig gene superfamily [2].
  • In this study, we investigated the candidacy of Fcgr1 and Cd101 for Idd10, by congenic mapping and candidate gene sequencing [3].


  1. Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice. Penha-Gonçalves, C., Moule, C., Smink, L.J., Howson, J., Gregory, S., Rogers, J., Lyons, P.A., Suttie, J.J., Lord, C.J., Peterson, L.B., Todd, J.A., Wicker, L.S. Diabetes (2003) [Pubmed]
  2. p126 (CDw101), a costimulatory molecule preferentially expressed on mucosal T lymphocytes. Russell, G.J., Parker, C.M., Sood, A., Mizoguchi, E., Ebert, E.C., Bhan, A.K., Brenner, M.B. J. Immunol. (1996) [Pubmed]
  3. Evidence for Cd101 but not Fcgr1 as candidate for type 1 diabetes locus, Idd10. Yamaji, K., Ikegami, H., Fujisawa, T., Noso, S., Nojima, K., Babaya, N., Itoi-Babaya, M., Makino, S., Sakamoto, T., Ogihara, T. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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