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Gene Review:

OTUB2 - OTU deubiquitinase, ubiquitin aldehyde...

Homo sapiens

Synonyms: C14orf137, Deubiquitinating enzyme OTUB2, FLJ21916, MGC3102, OTB2, ...

Nanao, M.H. et al., Balakirev, M.Y. et al.

Balakirev, Tcherniuk, Jaquinod, Chroboczek,

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High impact information on OTUB2

Although otubain 2 is a member of the cysteine protease superfamily of folds, its crystal structure shows a novel fold for DUBs [1].
Furthermore, the residues that orient and stabilize the active-site histidine of otubain 2 are different from other cysteine proteases [1].
We have named these proteins otubain 1 and otubain 2, for OTU-domain Ubal-binding protein [2].

References

Crystal structure of human otubain 2. Nanao, M.H., Tcherniuk, S.O., Chroboczek, J., Dideberg, O., Dessen, A., Balakirev, M.Y. EMBO Rep. (2004) [Pubmed]
Otubains: a new family of cysteine proteases in the ubiquitin pathway. Balakirev, M.Y., Tcherniuk, S.O., Jaquinod, M., Chroboczek, J. EMBO Rep. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

OTUB2	Bos taurus
OTUB2	Canis lupus familiaris
OTUB2	Macaca mulatta
Otub2	Mus musculus
OTUB2	Pan troglodytes
Otub2	Rattus norvegicus
otub2	Xenopus (Silurana) tropicalis

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