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Gene Review:

ATG9A - autophagy related 9A

Homo sapiens

Synonyms: APG9-like 1, APG9L1, Autophagy-related protein 9A, FLJ22169, MGD3208, ...

Yamada, T. et al.

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High impact information on ATG9A

In addition, APG9L2 can functionally complement APG9L1 in this process [1].
Finally, by the small interfering RNA-mediated knockdown of APG9L1 in HeLa cells, we demonstrated that APG9L1 is essential for starvation-induced autophagosome formation [1].
In human adult tissues, APG9L1 was ubiquitously expressed, whereas APG9L2 was highly expressed in placenta (trophoblast cells) and pituitary gland [1].

Analytical, diagnostic and therapeutic context of ATG9A

These results, taken together with those of phylogenetic and sequence analyses, suggest that both APG9L1 and APG9L2 are functionally orthologous to the yATG9 in autophagosome formation [1].

References

Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast. Yamada, T., Carson, A.R., Caniggia, I., Umebayashi, K., Yoshimori, T., Nakabayashi, K., Scherer, S.W. J. Biol. Chem. (2005) [Pubmed]

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