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Gene Review

CARD14  -  caspase recruitment domain family, member 14

Homo sapiens

Synonyms: BIMP2, CARD-containing MAGUK protein 2, CARMA2, Carma 2, Caspase recruitment domain-containing protein 14, ...
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High impact information on CARD14

  • We report here that CARD protein 11 (CARD11) and CARD protein 14 (CARD14) are novel CARD-containing proteins that belong to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane [1].
  • The CARD domains of both CARD11 and CARD14 associate specifically with the CARD domain of BCL10, a signaling protein that activates NF-kappaB through the IkappaB kinase complex in response to upstream stimuli [1].
  • Comparisons with acidity constants taken from the literature show that this latter pKa value is far too large and this allows the conclusion that an intramolecular hydrogen bond is formed between the (N-1/N-3)H site and the phosphonate group of Bimp2-; the formation degree of this hydrogen-bonded isomer is estimated to be 98 +/- 2% [2].

Biological context of CARD14


  1. CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B. Bertin, J., Wang, L., Guo, Y., Jacobson, M.D., Poyet, J.L., Srinivasula, S.M., Merriam, S., DiStefano, P.S., Alnemri, E.S. J. Biol. Chem. (2001) [Pubmed]
  2. Synthesis and acid-base properties of (1H-benzimidazol-2-yl-methyl)phosphonate (Bimp2-). Evidence for intramolecular hydrogen-bond formation in aqueous solution between (N-1)H and the phosphonate group. Sánchez-Moreno, M.J., Gómez-Coca, R.B., Fernández-Botello, A., Ochocki, J., Kotynski, A., Griesser, R., Sigel, H. Org. Biomol. Chem. (2003) [Pubmed]
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