Gene Review:
BCL10 - B-cell CLL/lymphoma 10
Homo sapiens
Synonyms:
B-cell lymphoma/leukemia 10, Bcl-10, CARD-containing molecule enhancing NF-kappa-B, CARD-like apoptotic protein, CARMEN, ...
Carter,
Briggs-Gowan,
Davis,
Hosokawa,
Bertin,
Guo,
Wang,
Srinivasula,
Jacobson,
Poyet,
Merriam,
Du,
Dyer,
Robison,
DiStefano,
Alnemri,
Gallardo,
Bellosillo,
Espinet,
Pujol,
Estrach,
Servitje,
Romagosa,
Barranco,
Boluda,
García,
Solé,
Ariza,
Serrano,
Sagaert,
Laurent,
Baens,
Wlodarska,
De Wolf-Peeters,
Holzmann,
Kohlhammer,
Schwaenen,
Wessendorf,
Kestler,
Schwoerer,
Rau,
Radlwimmer,
Döhner,
Lichter,
Gress,
Bentz,
- MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10. Nakagawa, M., Hosokawa, Y., Yonezumi, M., Izumiyama, K., Suzuki, R., Tsuzuki, S., Asaka, M., Seto, M. Blood (2005)
- Overexpression of caspase recruitment domain (CARD) membrane-associated guanylate kinase 1 (CARMA1) and CARD9 in primary gastric B-cell lymphoma. Nakamura, S., Nakamura, S., Matsumoto, T., Yada, S., Hirahashi, M., Suekane, H., Yao, T., Goda, K., Iida, M. Cancer (2005)
- Absence of BCL10 mutations in human malignant mesothelioma. Apostolou, S., De Rienzo, A., Murthy, S.S., Jhanwar, S.C., Testa, J.R. Cell (1999)
- BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma. Ye, H., Dogan, A., Karran, L., Willis, T.G., Chen, L., Wlodarska, I., Dyer, M.J., Isaacson, P.G., Du, M.Q. Am. J. Pathol. (2000)
- API2-MALT1 fusion defines a distinctive clinicopathologic subtype in pulmonary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. Okabe, M., Inagaki, H., Ohshima, K., Yoshino, T., Li, C., Eimoto, T., Ueda, R., Nakamura, S. Am. J. Pathol. (2003)
- Assessment of young children's social-emotional development and psychopathology: recent advances and recommendations for practice. Carter, A.S., Briggs-Gowan, M.J., Davis, N.O. Journal of child psychology and psychiatry, and allied disciplines. (2004)
- Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32). Zhang, Q., Siebert, R., Yan, M., Hinzmann, B., Cui, X., Xue, L., Rakestraw, K.M., Naeve, C.W., Beckmann, G., Weisenburger, D.D., Sanger, W.G., Nowotny, H., Vesely, M., Callet-Bauchu, E., Salles, G., Dixit, V.M., Rosenthal, A., Schlegelberger, B., Morris, S.W. Nat. Genet. (1999)
- Lack of BCL10 mutations in germ cell tumors and B cell lymphomas. Fakruddin, J.M., Chaganti, R.S., Murty, V.V. Cell (1999)
- The CARMA1-Bcl10 Signaling Complex Selectively Regulates JNK2 Kinase in the T Cell Receptor-Signaling Pathway. Blonska, M., Pappu, B.P., Matsumoto, R., Li, H., Su, B., Wang, D., Lin, X. Immunity (2007)
- The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Sun, L., Deng, L., Ea, C.K., Xia, Z.P., Chen, Z.J. Mol. Cell (2004)
- Genetic abnormalities in marginal zone B-cell lymphoma. Dierlamm, J., Wlodarska, I., Michaux, L., Stefanova, M., Hinz, K., Van Den Berghe, H., Hagemeijer, A., Hossfeld, D.K. Hematological oncology. (2000)
- Marginal-zone B-cell lymphoma of extranodal mucosa-associated lymphoid tissue type: molecular genetics provides new insights into pathogenesis. Vega, F., Medeiros, L.J. Advances in anatomic pathology. (2001)
- Anti-apoptotic action of API2-MALT1 fusion protein involved in t(11;18)(q21;q21) MALT lymphoma. Hosokawa, Y. Apoptosis (2005)
- Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B. Wang, L., Guo, Y., Huang, W.J., Ke, X., Poyet, J.L., Manji, G.A., Merriam, S., Glucksmann, M.A., DiStefano, P.S., Alnemri, E.S., Bertin, J. J. Biol. Chem. (2001)
- cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas. Hu, S., Du, M.Q., Park, S.M., Alcivar, A., Qu, L., Gupta, S., Tang, J., Baens, M., Ye, H., Lee, T.H., Marynen, P., Riley, J.L., Yang, X. J. Clin. Invest. (2006)
- T(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear BCL10. Liu, H., Ye, H., Dogan, A., Ranaldi, R., Hamoudi, R.A., Bearzi, I., Isaacson, P.G., Du, M.Q. Blood (2001)
- CLAN, a novel human CED-4-like gene. Damiano, J.S., Stehlik, C., Pio, F., Godzik, A., Reed, J.C. Genomics (2001)
- Bcl10 Controls TCR- and Fc{gamma}R-Induced Actin Polymerization. Rueda, D., Gaide, O., Ho, L., Lewkowicz, E., Niedergang, F., Hailfinger, S., Rebeaud, F., Guzzardi, M., Conne, B., Thelen, M., Delon, J., Ferch, U., Mak, T.W., Ruland, J., Schwaller, J., Thome, M. J. Immunol. (2007)
- CARMA3/Bcl10/MALT1-dependent NF-{kappa}B activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells. McAllister-Lucas, L.M., Ruland, J., Siu, K., Jin, X., Gu, S., Kim, D.S., Kuffa, P., Kohrt, D., Mak, T.W., Nu??ez, G., Lucas, P.C. Proc. Natl. Acad. Sci. U.S.A. (2007)
- Bcl10 and Malt1 control lysophosphatidic acid-induced NF-{kappa}B activation and cytokine production. Klemm, S., Zimmermann, S., Peschel, C., Mak, T.W., Ruland, J. Proc. Natl. Acad. Sci. U.S.A. (2007)
- CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B. Bertin, J., Guo, Y., Wang, L., Srinivasula, S.M., Jacobson, M.D., Poyet, J.L., Merriam, S., Du, M.Q., Dyer, M.J., Robison, K.E., DiStefano, P.S., Alnemri, E.S. J. Biol. Chem. (2000)
- CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation. Gaide, O., Favier, B., Legler, D.F., Bonnet, D., Brissoni, B., Valitutti, S., Bron, C., Tschopp, J., Thome, M. Nat. Immunol. (2002)
- Inhibition of Bcl10-mediated activation of NF-kappa B by BinCARD, a Bcl10-interacting CARD protein. Woo, H.N., Hong, G.S., Jun, J.I., Cho, D.H., Choi, H.W., Lee, H.J., Chung, C.W., Kim, I.K., Jo, D.G., Pyo, J.O., Bertin, J., Jung, Y.K. FEBS Lett. (2004)
- Characterization of Bcl10 as a potential transcriptional activator that interacts with general transcription factor TFIIB. Liu, Y., Dong, W., Chen, L., Zhang, P., Qi, Y. Biochem. Biophys. Res. Commun. (2004)
- CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B. Bertin, J., Wang, L., Guo, Y., Jacobson, M.D., Poyet, J.L., Srinivasula, S.M., Merriam, S., DiStefano, P.S., Alnemri, E.S. J. Biol. Chem. (2001)
- Distinct comparative genomic hybridisation profiles in gastric mucosa-associated lymphoid tissue lymphomas with and without t(11;18)(q21;q21). Zhou, Y., Ye, H., Martin-Subero, J.I., Hamoudi, R., Lu, Y.J., Wang, R., Siebert, R., Shipley, J., Isaacson, P.G., Dogan, A., Du, M.Q. Br. J. Haematol. (2006)
- Bcl10 can promote survival of antigen-stimulated B lymphocytes. Tian, M.T., Gonzalez, G., Scheer, B., DeFranco, A.L. Blood (2005)
- Genomic DNA-chip hybridization reveals a higher incidence of genomic amplifications in pancreatic cancer than conventional comparative genomic hybridization and leads to the identification of novel candidate genes. Holzmann, K., Kohlhammer, H., Schwaenen, C., Wessendorf, S., Kestler, H.A., Schwoerer, A., Rau, B., Radlwimmer, B., Döhner, H., Lichter, P., Gress, T., Bentz, M. Cancer Res. (2004)
- MALT1 and BCL10 aberrations in MALT lymphomas and their effect on the expression of BCL10 in the tumour cells. Sagaert, X., Laurent, M., Baens, M., Wlodarska, I., De Wolf-Peeters, C. Mod. Pathol. (2006)
- The Bcl10/Malt1 signaling pathway as a drug target in lymphoma. Jost, P., Peschel, C., Ruland, J. Current drug targets. (2006)
- Aberrant nuclear BCL10 expression and lack of t(11;18)(q21;q21) in primary cutaneous marginal zone B-cell lymphoma. Gallardo, F., Bellosillo, B., Espinet, B., Pujol, R.M., Estrach, T., Servitje, O., Romagosa, V., Barranco, C., Boluda, S., García, M., Solé, F., Ariza, A., Serrano, S. Hum. Pathol. (2006)
- Acral myxoinflammatory fibroblastic sarcoma with unique clonal chromosomal changes. Lambert, I., Debiec-Rychter, M., Guelinckx, P., Hagemeijer, A., Sciot, R. Virchows Arch. (2001)