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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DHX58  -  DEXH (Asp-Glu-X-His) box polypeptide 58

Homo sapiens

Synonyms: D11LGP2, D11LGP2E, D11lgp2e, LGP2, Protein D11Lgp2 homolog, ...
 
 
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Disease relevance of LGP2

  • LGP2 mRNA is induced by interferon, dsRNA treatments, or Sendai virus infection and acts as a feedback inhibitor for antiviral signaling [1].
 

High impact information on LGP2

  • We also found that LGP2, a helicase related to RIG-I and MDA5 but lacking CARDs and functioning as a negative regulator of host defense, binds HCV RNA [2].
  • Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity [3].
  • Another helicase protein, LGP2, lacks the CARD region and does not activate IFN-beta gene expression [1].
  • RNA- and Virus-Independent Inhibition of Antiviral Signaling by RNA Helicase LGP2 [1].

References

  1. RNA- and Virus-Independent Inhibition of Antiviral Signaling by RNA Helicase LGP2. Komuro, A., Horvath, C.M. J. Virol. (2006) [Pubmed]
  2. Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Saito, T., Hirai, R., Loo, Y.M., Owen, D., Johnson, C.L., Sinha, S.C., Akira, S., Fujita, T., Gale, M. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  3. Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. Yoneyama, M., Kikuchi, M., Matsumoto, K., Imaizumi, T., Miyagishi, M., Taira, K., Foy, E., Loo, Y.M., Gale, M., Akira, S., Yonehara, S., Kato, A., Fujita, T. J. Immunol. (2005) [Pubmed]
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