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Gene Review

C1orf35  -  chromosome 1 open reading frame 35

Homo sapiens

Synonyms: MGC4174, MMTAG2, Multiple myeloma tumor-associated protein 2, hMMTAG2
 
 
 
 
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Disease relevance of C1orf35

 

High impact information on C1orf35

  • The analysis of bioinformatics revealed that hMMTAG2 had many phosphorylation sites for several protein kinases, N-myristoylation sites and nuclear localization signals, so it may be a signal molecule in the nucleus [1].
  • It was located at chromosome 1q42.13. hMMTAG2 had same transforming activities in NIH/3T3 cells as the clone A62-17, and the number of transformant foci was 6 folds more than the blank vector pcDNA3.1(+) [1].
  • The full length of this sequence has 1300 bp and was named as hMMTAG2 gene. hMMTAG2 consists of 8 exons and codes for a polypeptide of 263 amino acids (the accession number in GenBank: AY137773) [1].

References

  1. Cloning and sequence analysis of tumor-associated gene hMMTAG2 from human multiple myeloma cell line ARH-77. Tian, J.Y., Hu, W.X., Tian, E.M., Shi, Y.W., Shen, Q.X., Tang, L.J., Jiang, Y.S. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (2003) [Pubmed]
 
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