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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

IRX6  -  iroquois homeobox 6

Homo sapiens

Synonyms: Homeodomain protein IRXB3, IRX-3, IRX7, IRXB3, Iroquois homeobox protein 6, ...
 
 
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High impact information on IRX6

  • Consistent with the role of Wnts as posteriorizing agents in neural tissue, we found that Wnt signaling was sufficient to induce Irx3 and repress Six3 expression in forebrain explants [1].
  • The position of the zona limitans intrathalamica (zli), a boundary-cell population that develops between the ventral (vT) and dorsal thalamus (dT), is predicted by the apposition of Six3 and Irx3 expression domains [1].
  • Targeted overexpression of Hoxa3 in the rostral hindbrain led to the generation of ectopic somatic motoneurones in ventral rhombomeres 1-4, and was accompanied by the repression of the dorsoventral patterning gene Irx3 [2].

References

  1. Wnt signaling is required at distinct stages of development for the induction of the posterior forebrain. Braun, M.M., Etheridge, A., Bernard, A., Robertson, C.P., Roelink, H. Development (2003) [Pubmed]
  2. Somatic motoneurone specification in the hindbrain: the influence of somite-derived signals, retinoic acid and Hoxa3. Guidato, S., Prin, F., Guthrie, S. Development (2003) [Pubmed]
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