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Gene Review:

BCL2L14 - BCL2-like 14 (apoptosis facilitator)

Homo sapiens

Synonyms: Apoptosis facilitator Bcl-2-like protein 14, Apoptosis regulator Bcl-G, BCL-G, BCLG, Bcl2-L-14

Guo, B. et al., Kibel, A.S. et al., Abdelhaleem, M. et al.

Kibel, Huagen, Guo, Isaacs, Yan, Pienta, Goodfellow,

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Disease relevance of BCL2L14

A novel TEL-AML1 fusion transcript involving the pro-apoptotic gene BCL-G in pediatric precursor B acute lymphoblastic leukemia [1].
DUSP16, FLJ10298 and BCLG were significantly downregulated in both clinical tumors and cultured prostate cancer tissue, indicating that one or all may be critical to initiation or progression of prostate carcinoma [2].

High impact information on BCL2L14

The human BCL-G gene consists of 6 exons, resides on chromosome 12p12, and encodes two proteins through alternative mRNA splicing, Bcl-G(L) (long) and Bcl-G(S) (short) consisting of 327 and 252 amino acids in length, respectively [3].

References

A novel TEL-AML1 fusion transcript involving the pro-apoptotic gene BCL-G in pediatric precursor B acute lymphoblastic leukemia. Abdelhaleem, M., Yi, Q., Beimnet, K., Hitzler, J. Leukemia (2006) [Pubmed]
Expression mapping at 12p12-13 in advanced prostate carcinoma. Kibel, A.S., Huagen, J., Guo, C., Isaacs, W.B., Yan, Y., Pienta, K.J., Goodfellow, P.J. Int. J. Cancer (2004) [Pubmed]
Bcl-G, a novel pro-apoptotic member of the Bcl-2 family. Guo, B., Godzik, A., Reed, J.C. J. Biol. Chem. (2001) [Pubmed]

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BCL2L14	Bos taurus
BCL2L14	Canis lupus familiaris
BCL2L14	Gallus gallus
BCL2L14	Macaca mulatta
Bcl2l14	Mus musculus
BCL2L14	Pan troglodytes
Bcl2l14	Rattus norvegicus
bcl2l14	Xenopus (Silurana) tropicalis
LOC101732952	Xenopus (Silurana) tropicalis

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