Gene Review:
RUNX1 - runt-related transcription factor 1
Homo sapiens
Synonyms:
AML1, AML1-EVI-1, AMLCR1, Acute myeloid leukemia 1 protein, CBF-alpha-2, ...
Hickstein,
Pritchard-Jones,
Rabbitts,
Moore,
Yoshikawa,
Chiba,
Foot,
Sabaawy,
Starost,
Kin,
Yamagishi,
Inaba,
Jean-Luc Laï,
Harada,
Kimura,
Franck-Emmanuel Nicolini,
Goff,
Downing,
Claude Preudhomme,
Nakase,
Nathalie Philippe,
Tanaka,
Sakakura,
Lillington,
Azuma,
Miyagawa,
Sun,
Catherine Roche-Lestienne,
Isabelle Tigaud,
Lauréline Deluche,
Patel,
Hagiwara,
Warren,
Yazumi,
Nakashima,
Lenny,
Hing,
Clark,
Williams,
Tsai,
Ito,
Sélim Corm,
Embree,
Ang,
Jones,
Harada,
Saha,
Sami Joha,
Bravo,
Sandrine Geffroy,
Ford,
Lorsbach,
Ito,
- A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis. Helms, C., Cao, L., Krueger, J.G., Wijsman, E.M., Chamian, F., Gordon, D., Heffernan, M., Daw, J.A., Robarge, J., Ott, J., Kwok, P.Y., Menter, A., Bowcock, A.M. Nat. Genet. (2003)
- Complex genomic alterations and gene expression in acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21. Strefford, J.C., van Delft, F.W., Robinson, H.M., Worley, H., Yiannikouris, O., Selzer, R., Richmond, T., Hann, I., Bellotti, T., Raghavan, M., Young, B.D., Saha, V., Harrison, C.J. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia. Zhang, Y., Strissel, P., Strick, R., Chen, J., Nucifora, G., Le Beau, M.M., Larson, R.A., Rowley, J.D. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia. Liu, S., Shen, T., Huynh, L., Klisovic, M.I., Rush, L.J., Ford, J.L., Yu, J., Becknell, B., Li, Y., Liu, C., Vukosavljevic, T., Whitman, S.P., Chang, K.S., Byrd, J.C., Perrotti, D., Plass, C., Marcucci, G. Cancer Res. (2005)
- RUNX1 DNA-binding mutations and RUNX1-PRDM16 cryptic fusions in BCR-ABL+ leukemias are frequently associated with secondary trisomy 21 and may contribute to clonal evolution and imatinib resistance. Roche-Lestienne, C., Deluche, L., Corm, S., Tigaud, I., Joha, S., Philippe, N., Geffroy, S., Laï, J.L., Nicolini, F.E., Preudhomme, C. Blood (2008)
- Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia. Harada, H., Harada, Y., Tanaka, H., Kimura, A., Inaba, T. Blood (2003)
- An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. Tokuhiro, S., Yamada, R., Chang, X., Suzuki, A., Kochi, Y., Sawada, T., Suzuki, M., Nagasaki, M., Ohtsuki, M., Ono, M., Furukawa, H., Nagashima, M., Yoshino, S., Mabuchi, A., Sekine, A., Saito, S., Takahashi, A., Tsunoda, T., Nakamura, Y., Yamamoto, K. Nat. Genet. (2003)
- A RUNX trio with a taste for autoimmunity. Alarcón-Riquelme, M.E. Nat. Genet. (2003)
- Acute lymphoblastic leukemia with TEL-AML1 fusion has lower expression of genes involved in purine metabolism and lower de novo purine synthesis. Zaza, G., Yang, W., Kager, L., Cheok, M., Downing, J., Pui, C.H., Cheng, C., Relling, M.V., Evans, W.E. Blood (2004)
- Analysis of RUNX1 binding site and RAPTOR polymorphisms in psoriasis: no evidence for association despite adequate power and evidence for linkage. Stuart, P., Nair, R.P., Abecasis, G.R., Nistor, I., Hiremagalore, R., Chia, N.V., Qin, Z.S., Thompson, R.A., Jenisch, S., Weichenthal, M., Janiga, J., Lim, H.W., Christophers, E., Voorhees, J.J., Elder, J.T. J. Med. Genet. (2006)
- The association of the TEL-AML1 chromosomal translocation with the accumulation of methotrexate polyglutamates in lymphoblasts and with ploidy in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study. Whitehead, V.M., Payment, C., Cooley, L., Lauer, S.J., Mahoney, D.H., Shuster, J.J., Vuchich, M.J., Bernstein, M.L., Look, A.T., Pullen, D.J., Camitta, B. Leukemia (2001)
- Effect of the histone deacetylase inhibitor depsipeptide on B-cell differentiation in both TEL-AML1-positive and negative childhood acute lymphoblastic leukemia. Stams, W.A., den Boer, M.L., Beverloo, H.B., Kazemier, K.M., van Wering, E.R., Janka-Schaub, G.E., Pieters, R. Haematologica (2005)
- Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling. Bourquin, J.P., Subramanian, A., Langebrake, C., Reinhardt, D., Bernard, O., Ballerini, P., Baruchel, A., Cavé, H., Dastugue, N., Hasle, H., Kaspers, G.L., Lessard, M., Michaux, L., Vyas, P., van Wering, E., Zwaan, C.M., Golub, T.R., Orkin, S.H. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Role of RUNX1 in adult hematopoiesis: analysis of RUNX1-IRES-GFP knock-in mice reveals differential lineage expression. Lorsbach, R.B., Moore, J., Ang, S.O., Sun, W., Lenny, N., Downing, J.R. Blood (2004)
- In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis. Michaud, J., Wu, F., Osato, M., Cottles, G.M., Yanagida, M., Asou, N., Shigesada, K., Ito, Y., Benson, K.F., Raskind, W.H., Rossier, C., Antonarakis, S.E., Israels, S., McNicol, A., Weiss, H., Horwitz, M., Scott, H.S. Blood (2002)
- RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation. Elagib, K.E., Racke, F.K., Mogass, M., Khetawat, R., Delehanty, L.L., Goldfarb, A.N. Blood (2003)
- A T lymphocyte-specific transcription complex containing RUNX1 activates MHC class I expression. Howcroft, T.K., Weissman, J.D., Gegonne, A., Singer, D.S. J. Immunol. (2005)
- A chromatin immunoprecipitation screen reveals protein kinase Cbeta as a direct RUNX1 target gene. Hug, B.A., Ahmed, N., Robbins, J.A., Lazar, M.A. J. Biol. Chem. (2004)
- The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding. Bäckström, S., Wolf-Watz, M., Grundström, C., Härd, T., Grundström, T., Sauer, U.H. J. Mol. Biol. (2002)
- The corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1. Imai, Y., Kurokawa, M., Yamaguchi, Y., Izutsu, K., Nitta, E., Mitani, K., Satake, M., Noda, T., Ito, Y., Hirai, H. Mol. Cell. Biol. (2004)
- Crystal structure of the nuclear matrix targeting signal of the transcription factor acute myelogenous leukemia-1/polyoma enhancer-binding protein 2alphaB/core binding factor alpha2. Tang, L., Guo, B., Javed, A., Choi, J.Y., Hiebert, S., Lian, J.B., van Wijnen, A.J., Stein, J.L., Stein, G.S., Zhou, G.W. J. Biol. Chem. (1999)
- A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells. Zhang, Y.W., Bae, S.C., Huang, G., Fu, Y.X., Lu, J., Ahn, M.Y., Kanno, Y., Kanno, T., Ito, Y. Mol. Cell. Biol. (1997)
- Cyclin-dependent kinase phosphorylation of RUNX1/AML1 on 3 sites increases transactivation potency and stimulates cell proliferation. Zhang, L., Fried, F.B., Guo, H., Friedman, A.D. Blood (2008)
- Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity. Zhao, X., Jankovic, V., Gural, A., Huang, G., Pardanani, A., Menendez, S., Zhang, J., Dunne, R., Xiao, A., Erdjument-Bromage, H., Allis, C.D., Tempst, P., Nimer, S.D. Genes Dev. (2008)
- Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene. Cho, J.Y., Akbarali, Y., Zerbini, L.F., Gu, X., Boltax, J., Wang, Y., Oettgen, P., Zhang, D.E., Libermann, T.A. J. Biol. Chem. (2004)
- Chromosome band 16q22-linked familial AML: exclusion of candidate genes, and possible disease risk modification by NQO1 polymorphisms. Escher, R., Jones, A., Hagos, F., Carmichael, C., Horwitz, M., Olopade, O.I., Scott, H.S. Genes Chromosomes Cancer (2004)
- Runx1 binds positive transcription elongation factor b and represses transcriptional elongation by RNA polymerase II: possible mechanism of CD4 silencing. Jiang, H., Zhang, F., Kurosu, T., Peterlin, B.M. Mol. Cell. Biol. (2005)
- Decreased intranuclear mobility of acute myeloid leukemia 1-containing fusion proteins is accompanied by reduced mobility and compartmentalization of core binding factor beta. Qiu, J., Wong, J., Tweardy, D.J., Dong, S. Oncogene (2006)
- The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes. Bakshi, R., Zaidi, S.K., Pande, S., Hassan, M.Q., Young, D.W., Montecino, M., Lian, J.B., van Wijnen, A.J., Stein, J.L., Stein, G.S. J. Cell. Sci. (2008)
- Expression profile of wild-type ETV6 in childhood acute leukaemia. Patel, N., Goff, L.K., Clark, T., Ford, A.M., Foot, N., Lillington, D., Hing, S., Pritchard-Jones, K., Jones, L.K., Saha, V. Br. J. Haematol. (2003)
- Intranuclear targeting of AML/CBFalpha regulatory factors to nuclear matrix-associated transcriptional domains. Zeng, C., McNeil, S., Pockwinse, S., Nickerson, J., Shopland, L., Lawrence, J.B., Penman, S., Hiebert, S., Lian, J.B., van Wijnen, A.J., Stein, J.L., Stein, G.S. Proc. Natl. Acad. Sci. U.S.A. (1998)
- RUNX expression and function in human B cells. Whiteman, H.J., Farrell, P.J. Crit. Rev. Eukaryot. Gene Expr. (2006)
- Overexpression of transcription factor BACH1 in fetal Down syndrome brain. Ferrando-Miguel, R., Cheon, M.S., Yang, J.W., Lubec, G. J. Neural Transm. Suppl. (2003)
- Transcriptional regulation of the human MIP-1alpha promoter by RUNX1 and MOZ. Bristow, C.A., Shore, P. Nucleic Acids Res. (2003)
- Mechanism of transcriptional repression by TEL/RUNX1 fusion protein. Lee, Y.J., Kim, J.H., Bae, S., Rho, S.K., Choe, S.Y. Mol. Cells (2004)
- The hematopoietic transcription factor AML1 (RUNX1) is negatively regulated by the cell cycle protein cyclin D3. Peterson, L.F., Boyapati, A., Ranganathan, V., Iwama, A., Tenen, D.G., Tsai, S., Zhang, D.E. Mol. Cell. Biol. (2005)
- Epigenetic consequences of AML1-ETO action at the human c-FMS locus. Follows, G.A., Tagoh, H., Lefevre, P., Hodge, D., Morgan, G.J., Bonifer, C. EMBO J. (2003)
- Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta. Warren, A.J., Bravo, J., Williams, R.L., Rabbitts, T.H. EMBO J. (2000)
- TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia. Sabaawy, H.E., Azuma, M., Embree, L.J., Tsai, H.J., Starost, M.F., Hickstein, D.D. Proc. Natl. Acad. Sci. U.S.A. (2006)
- The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family. Gamou, T., Kitamura, E., Hosoda, F., Shimizu, K., Shinohara, K., Hayashi, Y., Nagase, T., Yokoyama, Y., Ohki, M. Blood (1998)
- Identification of RUNX1/AML1 as a classical tumor suppressor gene. Silva, F.P., Morolli, B., Storlazzi, C.T., Anelli, L., Wessels, H., Bezrookove, V., Kluin-Nelemans, H.C., Giphart-Gassler, M. Oncogene (2003)
- RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription. Reed-Inderbitzin, E., Moreno-Miralles, I., Vanden-Eynden, S.K., Xie, J., Lutterbach, B., Durst-Goodwin, K.L., Luce, K.S., Irvin, B.J., Cleary, M.L., Brandt, S.J., Hiebert, S.W. Oncogene (2006)
- Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer. Sakakura, C., Hagiwara, A., Miyagawa, K., Nakashima, S., Yoshikawa, T., Kin, S., Nakase, Y., Ito, K., Yamagishi, H., Yazumi, S., Chiba, T., Ito, Y. Int. J. Cancer (2005)