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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CARF  -  calcium responsive transcription factor

Homo sapiens

Synonyms: ALS2CR8, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein, CaRF, Calcium-response factor, Calcium-responsive transcription factor, ...
 
 
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High impact information on ALS2CR8

  • In this issue of Neuron, report the discovery of a new transcription factor, CaRF, that contributes to calcium stimulation of the BDNF gene through CaRE1, one of several calcium response elements found in the promoter of the BDNF gene [1].
  • The CaRF/CaRE1 transcriptional pathway may control the expression of genes critical for activity-dependent, long-term changes in the central nervous system (CNS) [1].
  • Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control [2].
 

Biological context of ALS2CR8

References

  1. CaRF: a neuronal transcription factor that CaREs. Xia, Z., Storm, D.R. Neuron (2002) [Pubmed]
  2. Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control. Hasan, M.K., Yaguchi, T., Minoda, Y., Hirano, T., Taira, K., Wadhwa, R., Kaul, S.C. Biochem. J. (2004) [Pubmed]
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