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Gene Review

CARF  -  calcium responsive transcription factor

Homo sapiens

Synonyms: ALS2CR8, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein, CaRF, Calcium-response factor, Calcium-responsive transcription factor, ...
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High impact information on ALS2CR8

  • In this issue of Neuron, report the discovery of a new transcription factor, CaRF, that contributes to calcium stimulation of the BDNF gene through CaRE1, one of several calcium response elements found in the promoter of the BDNF gene [1].
  • The CaRF/CaRE1 transcriptional pathway may control the expression of genes critical for activity-dependent, long-term changes in the central nervous system (CNS) [1].
  • Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control [2].

Biological context of ALS2CR8


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