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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PDZD3  -  PDZ domain containing 3

Homo sapiens

Synonyms: DLNB27, FLJ22756, IKEPP, Intestinal and kidney-enriched PDZ protein, NHERF-4, ...
 
 
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High impact information on PDZD3

  • IKEPP is expressed in the intestinal epithelium, where it is preferentially accumulated at the apical surface [1].
  • Coexpression of PDZK2 did not affect carnitine transport activity of OCTN2 with deletion of the last four amino acids, which were found to be important for the interaction, suggesting involvement of physical interaction of the two proteins in the increase of cell surface expression of OCTN2 [2].
 

Other interactions of PDZD3

 

Analytical, diagnostic and therapeutic context of PDZD3

  • We identified a novel protein, IKEPP (intestinal and kidney-enriched PDZ protein) that associates with the COOH terminus of GCC in biochemical assays and by co-immunoprecipitation [1].

References

  1. A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor. Scott, R.O., Thelin, W.R., Milgram, S.L. J. Biol. Chem. (2002) [Pubmed]
  2. PDZ Adaptor Protein PDZK2 Stimulates Transport Activity of Organic Cation/Carnitine Transporter OCTN2 by Modulating Cell Surface Expression. Watanabe, C., Kato, Y., Sugiura, T., Kubo, Y., Wakayama, T., Iseki, S., Tsuji, A. Drug Metab. Dispos. (2006) [Pubmed]
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