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Gene Review

Actvty1  -  activity 1

Mus musculus

Synonyms: Act-1
 
 
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Disease relevance of Actvty1

  • METHODS: Activity of IL-18 was neutralized using recombinant human IL-18 binding protein isoform a (rhIL-18BPa) in trinitrobenzene sulfonic acid (TNBS)-induced colitis [1].
  • A Small Interfering CD147-Targeting RNA Inhibited the Proliferation, Invasiveness, and Metastatic Activity of Malignant Melanoma [2].
  • Clomesone exhibited significant antitumor activity against the murine L1210 leukemia implanted i.p., s.c., and intracerebrally (i.c.). Activity against s.c.-implanted tumor was largely independent of schedule and route of administration [3].
  • Mast Cell-Mediated Remodeling and Fibrinolytic Activity Protect against Fatal Glomerulonephritis [4].
  • Matrix Metalloproteinase 9 Activity Enhances Host Susceptibility to Pulmonary Infection with Type A and B Strains of Francisella tularensis [5].
 

Psychiatry related information on Actvty1

 

High impact information on Actvty1

 

Chemical compound and disease context of Actvty1

 

Biological context of Actvty1

 

Anatomical context of Actvty1

 

Associations of Actvty1 with chemical compounds

  • The regulatory factor Differentiation Inhibiting Activity/Leukaemia Inhibitory Factor (DIA/LIF) suppresses the differentiation of cultured embryonic stem (ES) cells [28].
  • Peptides Derived from the C2 Domain of Protein Kinase C{epsilon} ({epsilon}PKC) Modulate {epsilon}PKC Activity and Identify Potential Protein-Protein Interaction Surfaces [29].
  • The Role of the C-terminal Domain of Protein Tyrosine Phosphatase-1B in Phosphatase Activity and Substrate Binding [30].
  • Modulation of p38 Mitogen-Activated Protein Kinase Cascade and Metalloproteinase Activity in Diaphragm Muscle in Response to Free Radical Scavenger Administration in Dystrophin-Deficient Mdx Mice [31].
  • Mouse Ornithine Decarboxylase-like Gene Encodes an Antizyme Inhibitor Devoid of Ornithine and Arginine Decarboxylating Activity [32].
 

Other interactions of Actvty1

 

Analytical, diagnostic and therapeutic context of Actvty1

References

  1. Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-alpha production in mice. Ten Hove, T., Corbaz, A., Amitai, H., Aloni, S., Belzer, I., Graber, P., Drillenburg, P., van Deventer, S.J., Chvatchko, Y., Te Velde, A.A. Gastroenterology (2001) [Pubmed]
  2. A Small Interfering CD147-Targeting RNA Inhibited the Proliferation, Invasiveness, and Metastatic Activity of Malignant Melanoma. Chen, X., Lin, J., Kanekura, T., Su, J., Lin, W., Xie, H., Wu, Y., Li, J., Chen, M., Chang, J. Cancer Res. (2006) [Pubmed]
  3. Antitumor activity of 2-chloroethyl (methylsulfonyl)methanesulfonate (clomesone, NSC 33847) against selected tumor systems in mice. Dykes, D.J., Waud, W.R., Harrison, S.D., Laster, W.R., Griswold, D.P., Shealy, Y.F., Montgomery, J.A. Cancer Res. (1989) [Pubmed]
  4. Mast Cell-Mediated Remodeling and Fibrinolytic Activity Protect against Fatal Glomerulonephritis. Kanamaru, Y., Scandiuzzi, L., Essig, M., Brochetta, C., Guérin-Marchand, C., Tomino, Y., Monteiro, R.C., Peuchmaur, M., Blank, U. J. Immunol. (2006) [Pubmed]
  5. Matrix Metalloproteinase 9 Activity Enhances Host Susceptibility to Pulmonary Infection with Type A and B Strains of Francisella tularensis. Malik, M., Bakshi, C.S., McCabe, K., Catlett, S.V., Shah, A., Singh, R., Jackson, P.L., Gaggar, A., Metzger, D.W., Melendez, J.A., Blalock, J.E., Sellati, T.J. J. Immunol. (2007) [Pubmed]
  6. Cognitive and Physical Activity Differently Modulate Disease Progression in the Amyloid Precursor Protein (APP)-23 Model of Alzheimer's Disease. Wolf, S.A., Kronenberg, G., Lehmann, K., Blankenship, A., Overall, R., Staufenbiel, M., Kempermann, G. Biol. Psychiatry (2006) [Pubmed]
  7. SSR180711, a Novel Selective alpha7 Nicotinic Receptor Partial Agonist: (II) Efficacy in Experimental Models Predictive of Activity Against Cognitive Symptoms of Schizophrenia. Pichat, P., Bergis, O.E., Terranova, J.P., Urani, A., Duarte, C., Santucci, V., Gueudet, C., Voltz, C., Steinberg, R., Stemmelin, J., Oury-Donat, F., Avenet, P., Griebel, G., Scatton, B. Neuropsychopharmacology (2007) [Pubmed]
  8. Letter: Activity of glutethimide metabolite in human beings. Gold, M., Tassoni, E.M., Etzi, M.M., Mathew, G. N. Engl. J. Med. (1975) [Pubmed]
  9. Feedback suppression of the immune response in vitro. I. Activity of antigen-stimulated B cells. Zubler, R.H., Cantor, H., Benacerraf, B., Germain, R.N. J. Exp. Med. (1980) [Pubmed]
  10. Enhanced Antitumor Activity of Murine-Human Hybrid T-Cell Receptor (TCR) in Human Lymphocytes Is Associated with Improved Pairing and TCR/CD3 Stability. Cohen, C.J., Zhao, Y., Zheng, Z., Rosenberg, S.A., Morgan, R.A. Cancer Res. (2006) [Pubmed]
  11. Anticancer Activity of BIM-46174, a New Inhibitor of the Heterotrimeric G{alpha}/G{beta}{gamma} Protein Complex. Prévost, G.P., Lonchampt, M.O., Holbeck, S., Attoub, S., Zaharevitz, D., Alley, M., Wright, J., Brezak, M.C., Coulomb, H., Savola, A., Huchet, M., Chaumeron, S., Nguyen, Q.D., Forgez, P., Bruyneel, E., Bracke, M., Ferrandis, E., Roubert, P., Demarquay, D., Gespach, C., Kasprzyk, P.G. Cancer Res. (2006) [Pubmed]
  12. In vivo Activity of the Cleaved Form of Soluble Urokinase Receptor: A New Hematopoietic Stem/Progenitor Cell Mobilizer. Selleri, C., Montuori, N., Ricci, P., Visconte, V., Baiano, A., Carriero, M.V., Rotoli, B., Rossi, G., Ragno, P. Cancer Res. (2006) [Pubmed]
  13. Erlotinib Effectively Inhibits JAK2V617F Activity and Polycythemia Vera Cell Growth. Li, Z., Xu, M., Xing, S., Ho, W.T., Ishii, T., Li, Q., Fu, X., Zhao, Z.J. J. Biol. Chem. (2007) [Pubmed]
  14. FTY720 Ameliorates Th1-Mediated Colitis in Mice by Directly Affecting the Functional Activity of CD4+CD25+ Regulatory T Cells. Daniel, C., Sartory, N., Zahn, N., Geisslinger, G., Radeke, H.H., Stein, J.M. J. Immunol. (2007) [Pubmed]
  15. Glibenclamide, a Blocker of K+ATP Channels, Shows Antileishmanial Activity in Experimental Murine Cutaneous Leishmaniasis. Serrano-Mart??n, X., Payares, G., Mendoza-Le??n, A. Antimicrob. Agents Chemother. (2006) [Pubmed]
  16. The Anti-Trypanosoma cruzi Activity of Posaconazole in a Murine Model of Acute Chagas' Disease Is Less Dependent on Gamma Interferon than That of Benznidazole. Ferraz, M.L., Gazzinelli, R.T., Alves, R.O., Urbina, J.A., Romanha, A.J. Antimicrob. Agents Chemother. (2007) [Pubmed]
  17. Porphyromonas gingivalis Fimbriae Proactively Modulate {beta}2 Integrin Adhesive Activity and Promote Binding to and Internalization by Macrophages. Hajishengallis, G., Wang, M., Harokopakis, E., Triantafilou, M., Triantafilou, K. Infect. Immun. (2006) [Pubmed]
  18. Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfal binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo. Chikazu, D., Li, X., Kawaguchi, H., Sakuma, Y., Voznesensky, O.S., Adams, D.J., Xu, M., Hoshio, K., Katavic, V., Herschman, H.R., Raisz, L.G., Pilbeam, C.C. J. Bone Miner. Res. (2002) [Pubmed]
  19. Replication-deficient Adenovirus Induces Host Topoisomerase I Activity: Implications for Adenovirus-mediated Gene Expression. Zamir, G., Zeira, E., Gelman, A.E., Shaked, A., Olthoff, K.M., Eid, A., Galun, E. Mol. Ther. (2007) [Pubmed]
  20. Synthesis and antiviral evaluation of N-carboxamidine-substituted analogues of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine hydrochloride. Gabrielsen, B., Phelan, M.J., Barthel-Rosa, L., See, C., Huggins, J.W., Kefauver, D.F., Monath, T.P., Ussery, M.A., Chmurny, G.N., Schubert, E.M. J. Med. Chem. (1992) [Pubmed]
  21. Prevention of photoreceptor apoptosis by activation of the glucocorticoid receptor. Wenzel, A., Grimm, C., Seeliger, M.W., Jaissle, G., Hafezi, F., Kretschmer, R., Zrenner, E., Remé, C.E. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  22. Oscillatory Membrane Potential Response to Glucose in Islet {beta}-Cells: A Comparison of Islet-Cell Electrical Activity in Mouse and Rat. Manning Fox, J.E., Gyulkhandanyan, A.V., Satin, L.S., Wheeler, M.B. Endocrinology (2006) [Pubmed]
  23. Increased Natural CD4+CD25+ Regulatory T Cells and Their Suppressor Activity Do Not Contribute to Mortality in Murine Polymicrobial Sepsis. Scumpia, P.O., Delano, M.J., Kelly, K.M., O'malley, K.A., Efron, P.A., McAuliffe, P.F., Brusko, T., Ungaro, R., Barker, T., Wynn, J.L., Atkinson, M.A., Reeves, W.H., Clare Salzler, M.J., Moldawer, L.L. J. Immunol. (2006) [Pubmed]
  24. An Alternative Pathway of NF-{kappa}B Activation Results in Maturation and T Cell Priming Activity of Dendritic Cells Overexpressing a Mutated I{kappa}B{alpha}. Moore, F., Buonocore, S., Aksoy, E., Ouled-Haddou, N., Goriely, S., Lazarova, E., Paulart, F., Heirman, C., Vaeremans, E., Thielemans, K., Goldman, M., Flamand, V. J. Immunol. (2007) [Pubmed]
  25. Protein kinase activity at the inner membrane of mammalian mitochondria. Verdanis, A. J. Biol. Chem. (1977) [Pubmed]
  26. Molecular Characterization of New Selective Peroxisome Proliferator-Activated Receptor {gamma} Modulators With Angiotensin Receptor Blocking Activity. Schupp, M., Clemenz, M., Gineste, R., Witt, H., Janke, J., Helleboid, S., Hennuyer, N., Ruiz, P., Unger, T., Staels, B., Kintscher, U. Diabetes (2005) [Pubmed]
  27. Peroxisomal fatty acid oxidation disorders and 58 kDa sterol carrier protein X (SCPx). Activity measurements in liver and fibroblasts using a newly developed method. Ferdinandusse, S., Denis, S., van Berkel, E., Dacremont, G., Wanders, R.J. J. Lipid Res. (2000) [Pubmed]
  28. Establishment of germ-line-competent embryonic stem (ES) cells using differentiation inhibiting activity. Nichols, J., Evans, E.P., Smith, A.G. Development (1990) [Pubmed]
  29. Peptides Derived from the C2 Domain of Protein Kinase C{epsilon} ({epsilon}PKC) Modulate {epsilon}PKC Activity and Identify Potential Protein-Protein Interaction Surfaces. Brandman, R., Disatnik, M.H., Churchill, E., Mochly-Rosen, D. J. Biol. Chem. (2007) [Pubmed]
  30. The Role of the C-terminal Domain of Protein Tyrosine Phosphatase-1B in Phosphatase Activity and Substrate Binding. Picha, K.M., Patel, S.S., Mandiyan, S., Koehn, J., Wennogle, L.P. J. Biol. Chem. (2007) [Pubmed]
  31. Modulation of p38 Mitogen-Activated Protein Kinase Cascade and Metalloproteinase Activity in Diaphragm Muscle in Response to Free Radical Scavenger Administration in Dystrophin-Deficient Mdx Mice. Hnia, K., Hugon, G., Rivier, F., Masmoudi, A., Mercier, J., Mornet, D. Am. J. Pathol. (2007) [Pubmed]
  32. Mouse Ornithine Decarboxylase-like Gene Encodes an Antizyme Inhibitor Devoid of Ornithine and Arginine Decarboxylating Activity. L??pez-Contreras, A.J., L??pez-Garcia, C., Jim??nez-Cervantes, C., Cremades, A., Pe??afiel, R. J. Biol. Chem. (2006) [Pubmed]
  33. TGFbeta Protein Processing and Activity through TCR Triggering of Primary CD8+ T Regulatory Cells. M??noret, A., Myers, L.M., Lee, S.J., Mittler, R.S., Rossi, R.J., Vella, A.T. J. Immunol. (2006) [Pubmed]
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