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Gene Review

PGAP1  -  post-GPI attachment to proteins 1

Homo sapiens

Synonyms: Bst1, FLJ12377, GPI inositol-deacylase, ISPD3024, MRT42, ...
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High impact information on PGAP1

  • We also show that the remodeling requires the preceding PGAP1-mediated deacylation from inositol of GPI-APs in the endoplasmic reticulum [1].
  • Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p [2].
  • Substitution of a conserved putative catalytic serine with alanine resulted in a complete loss of function, indicating that PGAP1 is the GPI inositol-deacylase [2].
  • In addition, a pilot study using spinal cord obtained at autopsy from three patients with motor neurone disease and 12 control subjects indicated no increase in spinal cord ir-TRH, PGAP, or PEP in human motor neurone disease [3].
  • Palmitaldehyde acetal phosphatidic acid ( PGAP ) caused dose-dependent aggregation of human platelets resuspended in modified Tyrode medium, with a threshold concentration of 0.5-1 microM and an EC50 of 4 microM [4].

Biological context of PGAP1

  • The level of functional expression of rPEPT2 with PGAP varied depending on the carbon source used for cell growth, but was up to five times higher than that obtained with the commonly employed inducible alcohol oxidase 1 promoter (PAOX1) [5].

Anatomical context of PGAP1

  • Increased spinal cord levels of ir-TRH and PGAP and PEP activities were not observed in the 1-month-old wr mice [3].

Associations of PGAP1 with chemical compounds

  • Chlorpromazine, a calmodulin antagonist, similarly inhibited PGAP -induced MDA formation and irreversible aggregation, and at 100 microM abolished monophasic aggregation [4].
  • Mepacrine, a phospholipase A2 inhibitor, at 2.5 microM reduced PGAP -induced MDA formation and [14C]-5-HT release by the resuspended platelets without affecting irreversible aggregation; higher concentrations of mepacrine abolished all three responses [4].


  1. Fatty Acid Remodeling of GPI-anchored Proteins Is Required for Their Raft Association. Maeda, Y., Tashima, Y., Houjou, T., Fujita, M., Yoko-O, T., Jigami, Y., Taguchi, R., Kinoshita, T. Mol. Biol. Cell (2007) [Pubmed]
  2. Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p. Tanaka, S., Maeda, Y., Tashima, Y., Kinoshita, T. J. Biol. Chem. (2004) [Pubmed]
  3. Raised thyrotrophin-releasing hormone, pyroglutamylamino peptidase, and proline endopeptidase are present in the spinal cord of wobbler mice but not in human motor neurone disease. Court, J.A., McDermott, J.R., Gibson, A.M., Marshall, E., Bloxham, C.A., Perry, R.H., Edwardson, J.A. J. Neurochem. (1987) [Pubmed]
  4. Arachidonate metabolism, 5-hydroxytryptamine release and aggregation in human platelets activated by palmitaldehyde acetal phosphatidic acid. Brammer, J.P., Maguire, M.H. Br. J. Pharmacol. (1984) [Pubmed]
  5. Use of the glyceraldehyde-3-phosphate dehydrogenase promoter for production of functional mammalian membrane transport proteins in the yeast Pichia pastoris. Döring, F., Klapper, M., Theis, S., Daniel, H. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
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