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Gene Review

MAP3K19  -  mitogen-activated protein kinase kinase...

Homo sapiens

Synonyms: FLJ23074, Mitogen-activated protein kinase kinase kinase 19, RCK, Regulated in COPD, protein kinase, SPS1/STE20-related protein kinase YSK4, ...
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Disease relevance of YSK4

  • Immunohistochemical staining for cytokeratin 5 (using RCK 103 monoclonal antibody) in basal cells showed a normal staining pattern of basal cells in the DBM-fed calves and extensive basal cell proliferation and squamous metaplasia in the oestrogen-treated positive control animals [1].

High impact information on YSK4

  • The channel's eight ligand-binding domains, the RCK domains, form an octameric gating ring in which Ca(2+) binding induces conformational changes that open the channel [2].
  • These results provide insights into the quaternary organization of the KtrAB transporter and its mechanism of activation and show that the RCK-domain octameric ring model is generally applicable to other ion-transport systems [3].
  • Three methionine residues located within the regulator of conductance for K+ (RCK) domains confer oxidative sensitivity to large-conductance Ca2+-activated K+ channels [4].


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