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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Ion Transport

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Disease relevance of Ion Transport

  • However, alterations in airway ion transport, which lead to the devastating lung disease in CF patients, appear to be largely absent in the CF mouse models [1].
  • Gene transfer was quantitated by molecular techniques that detected the expression of CFTR messenger RNA and by functional measurements of transepithelial potential differences (PDs) to assess abnormalities of ion transport specific to cystic fibrosis [2].
  • Point mutations in rat adducin alpha (F316Y) and beta (Q529R) subunits are involved in a form of rat primary hypertension (MHS) associated with faster kidney tubular ion transport [3].
  • We conclude that diabetic diarrhea in streptozocin-induced chronically diabetic rats is due to impaired adrenergic regulation of mucosal ion transport, accompanied by a postsynaptic denervation hypersensitivity that can be reversed by clonidine, and accompanied by net intestinal fluid secretion that can be effectively reversed with clonidine [4].
  • Here, we investigate whether EGFR can regulate colonic ion transport in the setting of colitis [5].

Psychiatry related information on Ion Transport


High impact information on Ion Transport

  • The isoform with disrupted beta4-integrin binding (hCLCA1, pCLCA1, mCLCA3) alters epithelial mucus secretion and ion transport processes [10].
  • Although the NKCC has been studied for approximately 20 years, we are only beginning to frame the broad outlines of the structure, function, and regulation of this ubiquitous ion transport mechanism [11].
  • They have clarified how both peptide and steroid hormones, including aldosterone and estrogen, regulate ion transport by distal convoluted tubule cells [12].
  • Some of the CF mouse models accurately reflect the ion-transport abnormalities and disease phenotype seen in human CF patients, especially in gastrointestinal tissue [1].
  • Ion transport mechanisms in thick ascending limb of Henle's loop of mammalian nephron [13].

Chemical compound and disease context of Ion Transport


Biological context of Ion Transport


Anatomical context of Ion Transport


Associations of Ion Transport with chemical compounds

  • Ouabain-like activity in toad skin and its implications for endogenous regulation of ion transport [27].
  • Location of a delta-subunit region determining ion transport through the acetylcholine receptor channel [28].
  • Previous work with chimaeras between the Torpedo californica and bovine AChR delta-subunits has shown that the region comprising the hydrophobic segment M2 and its vicinity contains an important determinant of the rate of ion transport through the AChR channel [29].
  • Ion transport was successfully demonstrated by imaging Na+-K+ fluxes after the inhibition of Na+- and K+ -dependent adenosine triphosphatase with ouabain [30].
  • The past year has seen a flurry of activity in the area of protein-mediated hexose uniport [31].

Gene context of Ion Transport


Analytical, diagnostic and therapeutic context of Ion Transport


  1. Pathophysiology of gene-targeted mouse models for cystic fibrosis. Grubb, B.R., Boucher, R.C. Physiol. Rev. (1999) [Pubmed]
  2. A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis. Knowles, M.R., Hohneker, K.W., Zhou, Z., Olsen, J.C., Noah, T.L., Hu, P.C., Leigh, M.W., Engelhardt, J.F., Edwards, L.J., Jones, K.R. N. Engl. J. Med. (1995) [Pubmed]
  3. Hypertension-associated point mutations in the adducin alpha and beta subunits affect actin cytoskeleton and ion transport. Tripodi, G., Valtorta, F., Torielli, L., Chieregatti, E., Salardi, S., Trusolino, L., Menegon, A., Ferrari, P., Marchisio, P.C., Bianchi, G. J. Clin. Invest. (1996) [Pubmed]
  4. Experimental diabetic diarrhea in rats. Intestinal mucosal denervation hypersensitivity and treatment with clonidine. Chang, E.B., Fedorak, R.N., Field, M. Gastroenterology (1986) [Pubmed]
  5. Epidermal growth factor partially restores colonic ion transport responses in mouse models of chronic colitis. McCole, D.F., Rogler, G., Varki, N., Barrett, K.E. Gastroenterology (2005) [Pubmed]
  6. Lithium ion transport and affective disorders within families of bipolar patients. Identification of a major gene locus. Dorus, E., Cox, N.J., Gibbons, R.D., Shaughnessy, R., Pandey, G.N., Cloninger, C.R. Arch. Gen. Psychiatry (1983) [Pubmed]
  7. Acute adaptive cellular base uptake in rat duodenal epithelium. Akiba, Y., Furukawa, O., Guth, P.H., Engel, E., Nastaskin, I., Kaunitz, J.D. Am. J. Physiol. Gastrointest. Liver Physiol. (2001) [Pubmed]
  8. Cloning and characterization of murine neuromedin U receptors. Funes, S., Hedrick, J.A., Yang, S., Shan, L., Bayne, M., Monsma, F.J., Gustafson, E.L. Peptides (2002) [Pubmed]
  9. Nocturnal enuresis: correction of renal function by desmopressin and diclofenac. Natochin, Y.V., Kuznetsova, A.A. Pediatr. Nephrol. (2000) [Pubmed]
  10. Structure and function of CLCA proteins. Loewen, M.E., Forsyth, G.W. Physiol. Rev. (2005) [Pubmed]
  11. Sodium-potassium-chloride cotransport. Russell, J.M. Physiol. Rev. (2000) [Pubmed]
  12. Mammalian distal tubule: physiology, pathophysiology, and molecular anatomy. Reilly, R.F., Ellison, D.H. Physiol. Rev. (2000) [Pubmed]
  13. Ion transport mechanisms in thick ascending limb of Henle's loop of mammalian nephron. Greger, R. Physiol. Rev. (1985) [Pubmed]
  14. Altered chloride ion channel kinetics associated with the delta F508 cystic fibrosis mutation. Dalemans, W., Barbry, P., Champigny, G., Jallat, S., Dott, K., Dreyer, D., Crystal, R.G., Pavirani, A., Lecocq, J.P., Lazdunski, M. Nature (1991) [Pubmed]
  15. Glucose-induced changes in Na+/H+ antiport activity and gene expression in cultured vascular smooth muscle cells. Role of protein kinase C. Williams, B., Howard, R.L. J. Clin. Invest. (1994) [Pubmed]
  16. Cooperative binding of lactose and the phosphorylated phosphocarrier protein HPr(Ser-P) to the lactose/H+ symport permease of Lactobacillus brevis. Ye, J.J., Saier, M.H. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  17. Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes: implications for AIDS dementia complex. Benos, D.J., Hahn, B.H., Bubien, J.K., Ghosh, S.K., Mashburn, N.A., Chaikin, M.A., Shaw, G.M., Benveniste, E.N. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  18. Excretion of putrescine by the putrescine-ornithine antiporter encoded by the potE gene of Escherichia coli. Kashiwagi, K., Miyamoto, S., Suzuki, F., Kobayashi, H., Igarashi, K. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  19. Oxygen consumption and cellular ion transport: evidence for adenosine triphosphate to O2 ratio near 6 in intact cell. Harris, S.I., Balaban, R.S., Mandel, L.J. Science (1980) [Pubmed]
  20. Salt tolerance conferred by overexpression of a vacuolar Na+/H+ antiport in Arabidopsis. Apse, M.P., Aharon, G.S., Snedden, W.A., Blumwald, E. Science (1999) [Pubmed]
  21. Effect of 13-norleucin motilin on water and ion transport in the human jejunum. Kachel, G.W., Frase, L.L., Domschke, W., Chey, W.Y., Krejs, G.J. Gastroenterology (1984) [Pubmed]
  22. Theophylline-induced changes in ion transport and conductance in human small intestinal mucosa. Corbett, C.L., Isaacs, P.E., Hawker, P.C., Turnberg, L.A. Nature (1977) [Pubmed]
  23. Cloning and characterization of the thyroid iodide transporter. Dai, G., Levy, O., Carrasco, N. Nature (1996) [Pubmed]
  24. Cell pH in the rat proximal convoluted tubule. Regulation by luminal and peritubular pH and sodium concentration. Alpern, R.J., Chambers, M. J. Clin. Invest. (1986) [Pubmed]
  25. Effect of D-alanine methionine enkephalin amide on ion transport in rabbit ileum. Dobbins, J., Racusen, L., Binder, H.J. J. Clin. Invest. (1980) [Pubmed]
  26. Vasoactive intestinal polypeptide-induced chloride secretion by a colonic epithelial cell line. Direct participation of a basolaterally localized Na+,K+,Cl- cotransport system. Dharmsathaphorn, K., Mandel, K.G., Masui, H., McRoberts, J.A. J. Clin. Invest. (1985) [Pubmed]
  27. Ouabain-like activity in toad skin and its implications for endogenous regulation of ion transport. Flier, J.S. Nature (1978) [Pubmed]
  28. Location of a delta-subunit region determining ion transport through the acetylcholine receptor channel. Imoto, K., Methfessel, C., Sakmann, B., Mishina, M., Mori, Y., Konno, T., Fukuda, K., Kurasaki, M., Bujo, H., Fujita, Y. Nature (1986) [Pubmed]
  29. Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance. Imoto, K., Busch, C., Sakmann, B., Mishina, M., Konno, T., Nakai, J., Bujo, H., Mori, Y., Fukuda, K., Numa, S. Nature (1988) [Pubmed]
  30. Imaging elemental distribution and ion transport in cultured cells with ion microscopy. Chandra, S., Morrison, G.H. Science (1985) [Pubmed]
  31. Uniporters and anion antiporters. Hebert, D.N., Carruthers, A. Curr. Opin. Cell Biol. (1991) [Pubmed]
  32. Cystic fibrosis gene mutations and pancreatitis risk: relation to epithelial ion transport and trypsin inhibitor gene mutations. Noone, P.G., Zhou, Z., Silverman, L.M., Jowell, P.S., Knowles, M.R., Cohn, J.A. Gastroenterology (2001) [Pubmed]
  33. Constitutive and regulated secretion of secretory leukocyte proteinase inhibitor by human intestinal epithelial cells. Si-Tahar, M., Merlin, D., Sitaraman, S., Madara, J.L. Gastroenterology (2000) [Pubmed]
  34. Keratins modulate colonocyte electrolyte transport via protein mistargeting. Toivola, D.M., Krishnan, S., Binder, H.J., Singh, S.K., Omary, M.B. J. Cell Biol. (2004) [Pubmed]
  35. The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction. Levin, J.Z., Horvitz, H.R. J. Cell Biol. (1992) [Pubmed]
  36. Effect of neuropeptide Y on jejunal water and ion transport in humans. Holzer-Petsche, U., Petritsch, W., Hinterleitner, T., Eherer, A., Sperk, G., Krejs, G.J. Gastroenterology (1991) [Pubmed]
  37. Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel. Qian, Z., Okuhara, D., Abe, M.K., Rosner, M.R. J. Biol. Chem. (1999) [Pubmed]
  38. Pharmacologic modulation of salt and water in the airway epithelium in cystic fibrosis. Knowles, M.R., Olivier, K., Noone, P., Boucher, R.C. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  39. Gene therapy for cystic fibrosis using E1-deleted adenovirus: a phase I trial in the nasal cavity. The University of North Carolina at Chapel Hill. Boucher, R.C., Knowles, M.R., Johnson, L.G., Olsen, J.C., Pickles, R., Wilson, J.M., Engelhardt, J., Yang, Y., Grossman, M. Hum. Gene Ther. (1994) [Pubmed]
  40. CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells. Cozens, A.L., Yezzi, M.J., Kunzelmann, K., Ohrui, T., Chin, L., Eng, K., Finkbeiner, W.E., Widdicombe, J.H., Gruenert, D.C. Am. J. Respir. Cell Mol. Biol. (1994) [Pubmed]
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