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Gene Review:

ZC3H12A - zinc finger CCCH-type containing 12A

Homo sapiens

Synonyms: FLJ23231, MCP-induced protein 1, MCPIP, MCPIP1, Ribonuclease ZC3H12A, ...

Zhou, L. et al.

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Disease relevance of ZC3H12A

MCPIP transcript levels were much higher in the explanted human hearts with IHD than with nonischemic heart disease [1].

High impact information on ZC3H12A

Gene microarray analysis showed that when expressed in hiuman embryonic kidney 293 cells, MCPIP induced apoptotic gene families before causing cell death [1].

Analytical, diagnostic and therapeutic context of ZC3H12A

In situ hybridization showed the presence of MCPIP transcripts in the cardiomyocytes and immunohistochemistry showed that MCPIP was associated with the cardiomyocyte nuclei of apoptotic cardiomyocytes [1].

References

Monocyte chemoattractant protein-1 induces a novel transcription factor that causes cardiac myocyte apoptosis and ventricular dysfunction. Zhou, L., Azfer, A., Niu, J., Graham, S., Choudhury, M., Adamski, F.M., Younce, C., Binkley, P.F., Kolattukudy, P.E. Circ. Res. (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

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