The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Heart Diseases

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Heart Diseases


Psychiatry related information on Heart Diseases


High impact information on Heart Diseases


Chemical compound and disease context of Heart Diseases


Biological context of Heart Diseases


Anatomical context of Heart Diseases


Gene context of Heart Diseases

  • They also suggest that a deficiency of the PDK1 pathway might contribute to development of cardiac disease in humans [31].
  • Cyclooxygenase-2 (COX-2)-catalyzed synthesis of prostaglandin E(2) (PGE(2)) plays a key role in inflammation and its associated diseases, such as cancer and vascular heart disease [32].
  • Thus, our data establish corin as the physiological pro-ANP convertase and indicate that corin deficiency may contribute to hypertensive heart disease [33].
  • These defects lead to embryonic death at E14.5 and are similar to those observed in other mouse models of congenital heart disease, including Sox4 and Nfatc1 null embryos [34].
  • Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh [35].

Analytical, diagnostic and therapeutic context of Heart Diseases


  1. Identification of the gene (BBS1) most commonly involved in Bardet-Biedl syndrome, a complex human obesity syndrome. Mykytyn, K., Nishimura, D.Y., Searby, C.C., Shastri, M., Yen, H.J., Beck, J.S., Braun, T., Streb, L.M., Cornier, A.S., Cox, G.F., Fulton, A.B., Carmi, R., Lüleci, G., Chandrasekharappa, S.C., Collins, F.S., Jacobson, S.G., Heckenlively, J.R., Weleber, R.G., Stone, E.M., Sheffield, V.C. Nat. Genet. (2002) [Pubmed]
  2. Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major. Brittenham, G.M., Griffith, P.M., Nienhuis, A.W., McLaren, C.E., Young, N.S., Tucker, E.E., Allen, C.J., Farrell, D.E., Harris, J.W. N. Engl. J. Med. (1994) [Pubmed]
  3. The upper limit of physiologic cardiac hypertrophy in highly trained elite athletes. Pelliccia, A., Maron, B.J., Spataro, A., Proschan, M.A., Spirito, P. N. Engl. J. Med. (1991) [Pubmed]
  4. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Molkentin, J.D., Lu, J.R., Antos, C.L., Markham, B., Richardson, J., Robbins, J., Grant, S.R., Olson, E.N. Cell (1998) [Pubmed]
  5. Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Pashmforoush, M., Lu, J.T., Chen, H., Amand, T.S., Kondo, R., Pradervand, S., Evans, S.M., Clark, B., Feramisco, J.R., Giles, W., Ho, S.Y., Benson, D.W., Silberbach, M., Shou, W., Chien, K.R. Cell (2004) [Pubmed]
  6. Maternal phenylketonuria and hyperphenylalaninemia. An international survey of the outcome of untreated and treated pregnancies. Lenke, R.R., Levy, H.L. N. Engl. J. Med. (1980) [Pubmed]
  7. The safety of transdermal nicotine as an aid to smoking cessation in patients with cardiac disease. Joseph, A.M., Norman, S.M., Ferry, L.H., Prochazka, A.V., Westman, E.C., Steele, B.G., Sherman, S.E., Cleveland, M., Antonnucio, D.O., Hartman, N., McGovern, P.G. N. Engl. J. Med. (1996) [Pubmed]
  8. Hemodynamic effects of sildenafil in men with severe coronary artery disease. Herrmann, H.C., Chang, G., Klugherz, B.D., Mahoney, P.D. N. Engl. J. Med. (2000) [Pubmed]
  9. Comparative efficacy of selective serotonin reuptake inhibitors and tricyclics in the treatment of melancholia. Roose, S.P., Glassman, A.H., Attia, E., Woodring, S. The American journal of psychiatry. (1994) [Pubmed]
  10. Evaluation of the potential interaction between NaCl and prostaglandin inhibition in elderly individuals with isolated systolic hypertension. Alam, S., Purdie, D.M., Johnson, A.G. J. Hypertens. (1999) [Pubmed]
  11. Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss. Schönberger, J., Wang, L., Shin, J.T., Kim, S.D., Depreux, F.F., Zhu, H., Zon, L., Pizard, A., Kim, J.B., Macrae, C.A., Mungall, A.J., Seidman, J.G., Seidman, C.E. Nat. Genet. (2005) [Pubmed]
  12. Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Hiroi, Y., Kudoh, S., Monzen, K., Ikeda, Y., Yazaki, Y., Nagai, R., Komuro, I. Nat. Genet. (2001) [Pubmed]
  13. Effects of estrogen replacement on the progression of coronary-artery atherosclerosis. Herrington, D.M., Reboussin, D.M., Brosnihan, K.B., Sharp, P.C., Shumaker, S.A., Snyder, T.E., Furberg, C.D., Kowalchuk, G.J., Stuckey, T.D., Rogers, W.J., Givens, D.H., Waters, D. N. Engl. J. Med. (2000) [Pubmed]
  14. Association of the California Tobacco Control Program with declines in cigarette consumption and mortality from heart disease. Fichtenberg, C.M., Glantz, S.A. N. Engl. J. Med. (2000) [Pubmed]
  15. Effects of normal as compared with low hematocrit values in patients with cardiac disease undergoing hemodialysis and receiving epoetin. Sklar, A.H., Narsipur, S. N. Engl. J. Med. (1998) [Pubmed]
  16. Postmenopausal estrogen use and heart disease. Shapiro, S. N. Engl. J. Med. (1987) [Pubmed]
  17. Prevention of cardiac disease by subcutaneous deferoxamine in patients with thalassemia major. Wolfe, L., Olivieri, N., Sallan, D., Colan, S., Rose, V., Propper, R., Freedman, M.H., Nathan, D.G. N. Engl. J. Med. (1985) [Pubmed]
  18. Congenital heart disease in relation to maternal use of Bendectin and other drugs in early pregnancy. Zierler, S., Rothman, K.J. N. Engl. J. Med. (1985) [Pubmed]
  19. Regional myocardial metabolism of high-energy phosphates during isometric exercise in patients with coronary artery disease. Weiss, R.G., Bottomley, P.A., Hardy, C.J., Gerstenblith, G. N. Engl. J. Med. (1990) [Pubmed]
  20. Serious reaction to desmopressin in a child with cyanotic heart disease. Israels, S.J., Kobrinsky, N.L. N. Engl. J. Med. (1989) [Pubmed]
  21. Calmodulin kinase II inhibition protects against structural heart disease. Zhang, R., Khoo, M.S., Wu, Y., Yang, Y., Grueter, C.E., Ni, G., Price, E.E., Thiel, W., Guatimosim, S., Song, L.S., Madu, E.C., Shah, A.N., Vishnivetskaya, T.A., Atkinson, J.B., Gurevich, V.V., Salama, G., Lederer, W.J., Colbran, R.J., Anderson, M.E. Nat. Med. (2005) [Pubmed]
  22. Antifibrinolytic activity of apolipoprotein(a) in vivo: human apolipoprotein(a) transgenic mice are resistant to tissue plasminogen activator-mediated thrombolysis. Palabrica, T.M., Liu, A.C., Aronovitz, M.J., Furie, B., Lawn, R.M., Furie, B.C. Nat. Med. (1995) [Pubmed]
  23. Dystrophin deficiency markedly increases enterovirus-induced cardiomyopathy: a genetic predisposition to viral heart disease. Xiong, D., Lee, G.H., Badorff, C., Dorner, A., Lee, S., Wolf, P., Knowlton, K.U. Nat. Med. (2002) [Pubmed]
  24. Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications. Fang, Z.Y., Prins, J.B., Marwick, T.H. Endocr. Rev. (2004) [Pubmed]
  25. Oncogene links seen to heart disease, cholesterol. Blume, E. J. Natl. Cancer Inst. (1989) [Pubmed]
  26. Chagas' heart disease in the United States. Hagar, J.M., Rahimtoola, S.H. N. Engl. J. Med. (1991) [Pubmed]
  27. Diastolic dysfunction in hypertrophic cardiomyopathy. Effect on active force generation during systole. Gwathmey, J.K., Warren, S.E., Briggs, G.M., Copelas, L., Feldman, M.D., Phillips, P.J., Callahan, M., Schoen, F.J., Grossman, W., Morgan, J.P. J. Clin. Invest. (1991) [Pubmed]
  28. Eosinophil cationic granule proteins impair thrombomodulin function. A potential mechanism for thromboembolism in hypereosinophilic heart disease. Slungaard, A., Vercellotti, G.M., Tran, T., Gleich, G.J., Key, N.S. J. Clin. Invest. (1993) [Pubmed]
  29. Medical manipulation of the ductus arteriosus. Elliott, R.B., Starling, M.B., Neutze, J.M. Lancet (1975) [Pubmed]
  30. Contribution of external forces to left ventricular diastolic pressure. Implications for the clinical use of the Starling law. Dauterman, K., Pak, P.H., Maughan, W.L., Nussbacher, A., Ariê, S., Liu, C.P., Kass, D.A. Ann. Intern. Med. (1995) [Pubmed]
  31. Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia. Mora, A., Davies, A.M., Bertrand, L., Sharif, I., Budas, G.R., Jovanović, S., Mouton, V., Kahn, C.R., Lucocq, J.M., Gray, G.A., Jovanović, A., Alessi, D.R. EMBO J. (2003) [Pubmed]
  32. gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. Jiang, Q., Elson-Schwab, I., Courtemanche, C., Ames, B.N. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  33. Hypertension in mice lacking the proatrial natriuretic peptide convertase corin. Chan, J.C., Knudson, O., Wu, F., Morser, J., Dole, W.P., Wu, Q. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  34. Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation. Wang, B., Weidenfeld, J., Lu, M.M., Maika, S., Kuziel, W.A., Morrisey, E.E., Tucker, P.W. Development (2004) [Pubmed]
  35. Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh. Briegel, K.J., Baldwin, H.S., Epstein, J.A., Joyner, A.L. Development (2005) [Pubmed]
  36. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Stephens, N.G., Parsons, A., Schofield, P.M., Kelly, F., Cheeseman, K., Mitchinson, M.J. Lancet (1996) [Pubmed]
  37. Fatal myocardial disease associated with industrial exposure to cobalt. Kennedy, A., Dornan, J.D., King, R. Lancet (1981) [Pubmed]
  38. Cold pressor test in detection of coronary heart-disease and cardiomyopathy using technetium-99m gated blood-pool imaging. Wainwright, R.J., Brennand-Roper, D.A., Cueni, T.A., Sowton, E., Hilson, A.J., Maisey, M.N. Lancet (1979) [Pubmed]
  39. Cholesterol and violence: is there a connection? Golomb, B.A. Ann. Intern. Med. (1998) [Pubmed]
  40. Intravenous theophylline therapy: nomogram guidelines. Jusko, W.J., Koup, J.R., Vance, J.W., Schentag, J.J., Kuritzky, P. Ann. Intern. Med. (1977) [Pubmed]
WikiGenes - Universities