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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ELL3  -  elongation factor RNA polymerase II-like 3

Homo sapiens

Synonyms: FLJ22637, RNA polymerase II elongation factor ELL3
 
 
 
 
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High impact information on ELL3

  • The C-terminal domain of ELL, which we recently demonstrated to be required and sufficient for the immortalization of myeloid progenitor cells, shares strong similarities to the C-terminal domain of ELL3 [1].
  • ELL3 was localized by immunofluorescence to the nucleus of cells, and Northern analysis indicated that ELL3 is a testis-specific RNA polymerase II elongation factor [1].
 

Other interactions of ELL3

  • Our transcriptional studies have demonstrated that ELL3 can also increase the catalytic rate of transcription elongation by RNA polymerase II [1].

References

  1. Identification, cloning, expression, and biochemical characterization of the testis-specific RNA polymerase II elongation factor ELL3. Miller, T., Williams, K., Johnstone, R.W., Shilatifard, A. J. Biol. Chem. (2000) [Pubmed]
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