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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Myeloid Progenitor Cells

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Disease relevance of Myeloid Progenitor Cells


High impact information on Myeloid Progenitor Cells


Chemical compound and disease context of Myeloid Progenitor Cells


Biological context of Myeloid Progenitor Cells


Anatomical context of Myeloid Progenitor Cells


Associations of Myeloid Progenitor Cells with chemical compounds


Gene context of Myeloid Progenitor Cells

  • Cytokines such as IL-6, tumor necrosis factor (TNF)-alpha, and IL-1, products of cells of the myeloid lineage, are known to be involved in growth control of myeloid progenitor cells [30].
  • We found that human CD34(+) cells and CD34(+)KIT(+) cells, which are enriched in myeloid progenitor cells, expressed and secreted the CCR5 ligands RANTES, MIP-1alpha, and MIP-1beta and that IFN-gamma stimulated expression of these chemokines [31].
  • In order to assess the involvement of Notch1 signalling in myelopoiesis, 32D myeloid progenitor cell lines were engineered to permit the conditional induction of the constitutively active intracellular domain of murine Notch1 (mN1(IC)) by the 4-hydroxytamoxifen-inducible system [32].
  • We report that 32D cells, an IL-3-dependent myeloid progenitor cell line in which no phosphorylated 4PS is found, activate high levels of STF-IL4 in response to IL-4 [33].
  • CD33 is a myeloid specific member of the sialic acid-binding receptor family and is expressed highly on myeloid progenitor cells but at much lower levels in differentiated cells [34].

Analytical, diagnostic and therapeutic context of Myeloid Progenitor Cells


  1. Kostmann syndrome: severe congenital neutropenia associated with defective expression of Bcl-2, constitutive mitochondrial release of cytochrome c, and excessive apoptosis of myeloid progenitor cells. Carlsson, G., Aprikyan, A.A., Tehranchi, R., Dale, D.C., Porwit, A., Hellström-Lindberg, E., Palmblad, J., Henter, J.I., Fadeel, B. Blood (2004) [Pubmed]
  2. Bcr-Abl kinase down-regulates cyclin-dependent kinase inhibitor p27 in human and murine cell lines. Jonuleit, T., van der Kuip, H., Miething, C., Michels, H., Hallek, M., Duyster, J., Aulitzky, W.E. Blood (2000) [Pubmed]
  3. hnRNP A1 nucleocytoplasmic shuttling activity is required for normal myelopoiesis and BCR/ABL leukemogenesis. Iervolino, A., Santilli, G., Trotta, R., Guerzoni, C., Cesi, V., Bergamaschi, A., Gambacorti-Passerini, C., Calabretta, B., Perrotti, D. Mol. Cell. Biol. (2002) [Pubmed]
  4. Identification of cyclin D3 as a direct target of E2A using DamID. Song, S., Cooperman, J., Letting, D.L., Blobel, G.A., Choi, J.K. Mol. Cell. Biol. (2004) [Pubmed]
  5. Effect of human immunodeficiency virus type-1 envelope glycoprotein gp160 on cytokine production from cord-blood T cells. Than, S., Oyaizu, N., Pahwa, R.N., Kalyanaraman, V.S., Pahwa, S. Blood (1994) [Pubmed]
  6. Role of IRS-2 in insulin and cytokine signalling. Sun, X.J., Wang, L.M., Zhang, Y., Yenush, L., Myers, M.G., Glasheen, E., Lane, W.S., Pierce, J.H., White, M.F. Nature (1995) [Pubmed]
  7. The human gene encoding GM-CSF is at 5q21-q32, the chromosome region deleted in the 5q- anomaly. Huebner, K., Isobe, M., Croce, C.M., Golde, D.W., Kaufman, S.E., Gasson, J.C. Science (1985) [Pubmed]
  8. Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation. Kieslinger, M., Woldman, I., Moriggl, R., Hofmann, J., Marine, J.C., Ihle, J.N., Beug, H., Decker, T. Genes Dev. (2000) [Pubmed]
  9. ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages. Tamura, T., Nagamura-Inoue, T., Shmeltzer, Z., Kuwata, T., Ozato, K. Immunity (2000) [Pubmed]
  10. Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia. Traver, D., Akashi, K., Weissman, I.L., Lagasse, E. Immunity (1998) [Pubmed]
  11. A phase 1B trial of humanized monoclonal antibody M195 (anti-CD33) in myeloid leukemia: specific targeting without immunogenicity. Caron, P.C., Jurcic, J.G., Scott, A.M., Finn, R.D., Divgi, C.R., Graham, M.C., Jureidini, I.M., Sgouros, G., Tyson, D., Old, L.J. Blood (1994) [Pubmed]
  12. In vitro antiproliferative activity of the farnesyltransferase inhibitor R115777 in hematopoietic progenitors from patients with myelofibrosis with myeloid metaplasia. Mesa, R.A., Tefferi, A., Gray, L.A., Reeder, T., Schroeder, G., Kaufmann, S.H. Leukemia (2003) [Pubmed]
  13. Swainsonine protects both murine and human haematopoietic systems from chemotherapeutic toxicity. Klein, J.L., Roberts, J.D., George, M.D., Kurtzberg, J., Breton, P., Chermann, J.C., Olden, K. Br. J. Cancer (1999) [Pubmed]
  14. Methimazole-induced agranulocytosis: growth inhibition of myeloid progenitor cells by the patient's serum. Douer, D., Eisenstein, Z. Eur. J. Haematol. (1988) [Pubmed]
  15. Toxicity of HPA-23 (ammonium-21-tungsto-9-antimoniate) for normal human myeloid progenitor cells (GM-CFU) in vitro. Aymard, J.P., Ferry, R., Janot, C., Schooneman, F., Legras, B., May, T., Streiff, F. Biomed. Pharmacother. (1989) [Pubmed]
  16. Association between colony forming units-granulocyte macrophage expression of Ia-like (HLA-DR) antigen and control of granulocyte and macrophage production. A new role for prostaglandin E. Pelus, L.M. J. Clin. Invest. (1982) [Pubmed]
  17. Deletion of alpha4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing. Scott, L.M., Priestley, G.V., Papayannopoulou, T. Mol. Cell. Biol. (2003) [Pubmed]
  18. Shc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells. Lioubin, M.N., Myles, G.M., Carlberg, K., Bowtell, D., Rohrschneider, L.R. Mol. Cell. Biol. (1994) [Pubmed]
  19. A new X-linked variant of chronic granulomatous disease characterized by the existence of a normal clone of respiratory burst-competent phagocytic cells. Woodman, R.C., Newburger, P.E., Anklesaria, P., Erickson, R.W., Rae, J., Cohen, M.S., Curnutte, J.T. Blood (1995) [Pubmed]
  20. Signaling through the interaction of membrane-restricted stem cell factor and c-kit receptor tyrosine kinase: genetic evidence for a differential role in erythropoiesis. Kapur, R., Majumdar, M., Xiao, X., McAndrews-Hill, M., Schindler, K., Williams, D.A. Blood (1998) [Pubmed]
  21. Essential and instructive roles of GATA factors in eosinophil development. Hirasawa, R., Shimizu, R., Takahashi, S., Osawa, M., Takayanagi, S., Kato, Y., Onodera, M., Minegishi, N., Yamamoto, M., Fukao, K., Taniguchi, H., Nakauchi, H., Iwama, A. J. Exp. Med. (2002) [Pubmed]
  22. CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein. Zhang, Y., Morrone, G., Zhang, J., Chen, X., Lu, X., Ma, L., Moore, M., Zhou, P. EMBO J. (2003) [Pubmed]
  23. Modulation of gene expression in multiple hematopoietic cell lineages following retroviral vector gene transfer. Magli, M.C., Dick, J.E., Huszar, D., Bernstein, A., Phillips, R.A. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  24. A functional analysis of protooncogene Vav's role in adult human hematopoiesis. Luger, S.M., Ratajczak, J., Ratajczak, M.Z., Kuczynski, W.I., DiPaola, R.S., Ngo, W., Clevenger, C.V., Gewirtz, A.M. Blood (1996) [Pubmed]
  25. Antibody stimulation of hemopoietic progenitor cells. Crapper, R.M., Schrader, J.W. Blood (1985) [Pubmed]
  26. A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies. Almind, K., Inoue, G., Pedersen, O., Kahn, C.R. J. Clin. Invest. (1996) [Pubmed]
  27. Regulation of Jak2 tyrosine kinase by protein kinase C during macrophage differentiation of IL-3-dependent myeloid progenitor cells. Kovanen, P.E., Junttila, I., Takaluoma, K., Saharinen, P., Valmu, L., Li, W., Silvennoinen, O. Blood (2000) [Pubmed]
  28. Deoxycytidine preferentially protects normal versus leukemic myeloid progenitor cells from cytosine arabinoside-mediated cytotoxicity. Bhalla, K., MacLaughlin, W., Cole, J., Arlin, Z., Baker, M., Graham, G., Grant, S. Blood (1987) [Pubmed]
  29. The influence in vivo of murine colony-stimulating factor-1 on myeloid progenitor cells in mice recovering from sublethal dosages of cyclophosphamide. Broxmeyer, H.E., Williams, D.E., Cooper, S., Waheed, A., Shadduck, R.K. Blood (1987) [Pubmed]
  30. Participation of the cytokines interleukin 6, tumor necrosis factor-alpha, and interleukin 1-beta secreted by acute myelogenous leukemia blasts in autocrine and paracrine leukemia growth control. Oster, W., Cicco, N.A., Klein, H., Hirano, T., Kishimoto, T., Lindemann, A., Mertelsmann, R.H., Herrmann, F. J. Clin. Invest. (1989) [Pubmed]
  31. Bone marrow CD34(+) cells and megakaryoblasts secrete beta-chemokines that block infection of hematopoietic cells by M-tropic R5 HIV. Majka, M., Rozmyslowicz, T., Lee, B., Murphy, S.L., Pietrzkowski, Z., Gaulton, G.N., Silberstein, L., Ratajczak, M.Z. J. Clin. Invest. (1999) [Pubmed]
  32. Notch signalling via RBP-J promotes myeloid differentiation. Schroeder, T., Just, U. EMBO J. (2000) [Pubmed]
  33. Interleukin 4 signals through two related pathways. Pernis, A., Witthuhn, B., Keegan, A.D., Nelms, K., Garfein, E., Ihle, J.N., Paul, W.E., Pierce, J.H., Rothman, P. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  34. Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2. Paul, S.P., Taylor, L.S., Stansbury, E.K., McVicar, D.W. Blood (2000) [Pubmed]
  35. Persistence of myeloid progenitor cells expressing BCR-ABL mRNA after allogeneic bone marrow transplantation for chronic myelogenous leukemia. Pichert, G., Alyea, E.P., Soiffer, R.J., Roy, D.C., Ritz, J. Blood (1994) [Pubmed]
  36. Interleukin 3, granulocyte-macrophage colony-stimulating factor, and transfected erythropoietin receptors mediate tyrosine phosphorylation of a common cytosolic protein (pp100) in FDC-ER cells. Quelle, F.W., Quelle, D.E., Wojchowski, D.M. J. Biol. Chem. (1992) [Pubmed]
  37. Estrone potentiates myeloid cell differentiation: a role for 17 beta-hydroxysteroid dehydrogenase in modulating hemopoiesis. Mountford, J.C., Bunce, C.M., Hughes, S.V., Drayson, M.T., Webb, D., Brown, G., Hewison, M. Exp. Hematol. (1999) [Pubmed]
  38. Differential responses of myeloid progenitor cells from patients with myeloid leukemia and myelodysplasia to the costimulating effects of steel factor in vitro. Maze, R., Horie, M., Hendrie, P., Vadhan-Raj, S., Tricot, G., Gordon, M., Nemunaitis, J., Ashman, L.K., Broxmeyer, H.E. Exp. Hematol. (1993) [Pubmed]
  39. Characterization of caspase proteases in cytokine-dependent myeloid progenitor cells using enzyme affinity labeling. Cho, R.L., Johnson, D.E. J. Cell. Biochem. (1999) [Pubmed]
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