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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ITPKC  -  inositol-trisphosphate 3-kinase C

Homo sapiens

Synonyms: IP3 3-kinase C, IP3-3KC, IP3K C, IP3KC, Inositol 1,4,5-trisphosphate 3-kinase C, ...
 
 
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High impact information on ITPKC

  • In the present study we examined the expression and intracellular localisation of endogenous IP3K-C in different mammalian cell lines using an isoform-specific antibody [1].
  • Whereas predominant targeting to the cytoskeleton and endoplasmic reticulum has been shown for IP3K-A and IP3K-B, rat IP3K-C shuttles actively between the nucleus and cytoplasm [1].
  • In addition, human IP3K-C, showing remarkable differences to its rat homologue in the N-terminal targeting domain, was tagged with EGFP and used to examine active transport mechanisms into and out of the nucleus [1].

References

  1. Subcellular localisation of human inositol 1,4,5-trisphosphate 3-kinase C: species-specific use of alternative export sites for nucleo-cytoplasmic shuttling indicates divergent roles of the catalytic and N-terminal domains. Nalaskowski, M.M., Windhorst, S., Stockebrand, M.C., Mayr, G.W. Biol. Chem. (2006) [Pubmed]
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