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FLAD1  -  flavin adenine dinucleotide synthetase 1

Homo sapiens

Synonyms: FAD pyrophosphorylase, FAD synthase, FAD1, FADS, FMN adenylyltransferase, ...
 
 
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Disease relevance of FLAD1

 

High impact information on FLAD1

  • We recently provided evidence for the regulation of caspase-1 activity via an endogenous inhibitor expressed by human vascular smooth muscle cells (SMCs) (Schönbeck, U., M. Herzberg, A. Petersen, C. Wohlenberg, J. Gerdes, H.-D. Flad, and H. Loppnow. 1997. J. Exp. Med. 185:1287-1294) [3].
  • The human isoform 2 of FADS (hFADS2), which is the product of FLAD1 gene, was over-expressed in Escherichia coli as a T7-tagged protein and identified by MALDI-TOF MS analysis [4].
  • Sixty-two patients with high-risk acute leukemia were treated with the FLAD regimen [3 days of treatment with fludarabine 30 mg/m(2), cytarabine (AraC) 2 g/m(2), and liposomal daunorubicin 80 mg/m(2)] [5].

References

  1. Over-expression in Escherichia coli and characterization of two recombinant isoforms of human FAD synthetase. Brizio, C., Galluccio, M., Wait, R., Torchetti, E.M., Bafunno, V., Accardi, R., Gianazza, E., Indiveri, C., Barile, M. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  2. Role of liposomal daunorubicin, fludarabine and cytarabine (FLAD) in the salvage therapy of adult acute lymphoblastic leukemia. Clavio, M., Pierri, I., Venturino, C., Garrone, A., Canepa, L., Miglino, M., Varaldo, R., Ballerini, F., Michelis, G.L., Balocco, M., Abdall, N., Gatto, S., Gobbi, M. Leuk. Lymphoma (2004) [Pubmed]
  3. The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells. Young, J.L., Sukhova, G.K., Foster, D., Kisiel, W., Libby, P., Schönbeck, U. J. Exp. Med. (2000) [Pubmed]
  4. Over-expression in Escherichia coli, purification and characterization of isoform 2 of human FAD synthetase. Galluccio, M., Brizio, C., Torchetti, E.M., Ferranti, P., Gianazza, E., Indiveri, C., Barile, M. Protein Expr. Purif. (2007) [Pubmed]
  5. Combination of liposomal daunorubicin (DaunoXome), fludarabine, and cytarabine (FLAD) in patients with poor-risk acute leukemia. Clavio, M., Venturino, C., Pierri, I., Garrone, A., Miglino, M., Canepa, L., Balleari, E., Balocco, M., Michelis, G.L., Ballerini, F., Gobbi, M. Ann. Hematol. (2004) [Pubmed]
 
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