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Gene Review

THAP7  -  THAP domain containing 7

Homo sapiens

Synonyms: MGC10963, THAP domain-containing protein 7
 
 
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High impact information on THAP7

  • Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor [1].
  • Full repression mediated by THAP7 is also dependent on NCoR expression [1].
  • Deletion of this domain, or treatment of cells with the histone deacetylase inhibitor TSA, which leads to histone hyperacetylation, partially disrupts THAP7/chromatin association in living cells [1].
  • Similarly, stably transfected THAP7 associates with endogenous TAF-Ibeta in intact cells [2].
 

Analytical, diagnostic and therapeutic context of THAP7

  • Chromatin immunoprecipitation assays demonstrate that these corepressors are recruited to promoters in a THAP7 dependent manner and promote histone H3 hypoacetylation [1].
  • We hypothesize that THAP7 is a dual function repressor protein that actively targets deacetylation of histone H3 necessary to establish transcriptional repression and functions as a signal transducer of the repressive mark of hypoacetylated histone H4 [1].

References

 
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