High impact information on THAP7

• Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor [1].
• Full repression mediated by THAP7 is also dependent on NCoR expression [1].
• Deletion of this domain, or treatment of cells with the histone deacetylase inhibitor TSA, which leads to histone hyperacetylation, partially disrupts THAP7/chromatin association in living cells [1].
• Similarly, stably transfected THAP7 associates with endogenous TAF-Ibeta in intact cells [2].

Analytical, diagnostic and therapeutic context of THAP7

• Chromatin immunoprecipitation assays demonstrate that these corepressors are recruited to promoters in a THAP7 dependent manner and promote histone H3 hypoacetylation [1].
• We hypothesize that THAP7 is a dual function repressor protein that actively targets deacetylation of histone H3 necessary to establish transcriptional repression and functions as a signal transducer of the repressive mark of hypoacetylated histone H4 [1].

References