Gene Review:
SET - SET nuclear proto-oncogene
Homo sapiens
Synonyms:
2PP2A, HLA-DR-associated protein II, I-2PP2A, I2PP2A, IGAAD, ...
- Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Fan, Z., Beresford, P.J., Oh, D.Y., Zhang, D., Lieberman, J. Cell (2003)
- The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A. Li, M., Makkinje, A., Damuni, Z. J. Biol. Chem. (1996)
- Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis. Nagata, K., Kawase, H., Handa, H., Yano, K., Yamasaki, M., Ishimi, Y., Okuda, A., Kikuchi, A., Matsumoto, K. Proc. Natl. Acad. Sci. U.S.A. (1995)
- PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET. Anazawa, Y., Nakagawa, H., Furihara, M., Ashida, S., Tamura, K., Yoshioka, H., Shuin, T., Fujioka, T., Katagiri, T., Nakamura, Y. Cancer Res. (2005)
- Bone mineral density in a native population of Argentina with low calcium intake. Spindler, A., Lucero, E., Berman, A., Paz, S., Vega, E., Mautalen, C. J. Rheumatol. (1995)
- Thrombin-mediated activation of factor XI results in a thrombin-activatable fibrinolysis inhibitor-dependent inhibition of fibrinolysis. Von dem Borne, P.A., Bajzar, L., Meijers, J.C., Nesheim, M.E., Bouma, B.N. J. Clin. Invest. (1997)
- Thrombin-activatable fibrinolysis inhibitor deficiency in cirrhosis is not associated with increased plasma fibrinolysis. Lisman, T., Leebeek, F.W., Mosnier, L.O., Bouma, B.N., Meijers, J.C., Janssen, H.L., Nieuwenhuis, H.K., De Groot, P.G. Gastroenterology (2001)
- Rac1-induced cell migration requires membrane recruitment of the nuclear oncogene SET. Ten Klooster, J.P., Leeuwen, I.V., Scheres, N., Anthony, E.C., Hordijk, P.L. EMBO J. (2007)
- A novel estrogen receptor alpha-associated protein, template-activating factor Ibeta, inhibits acetylation and transactivation. Loven, M.A., Muster, N., Yates, J.R., Nardulli, A.M. Mol. Endocrinol. (2003)
- Insulin resistance is associated with increased circulating level of thrombin-activatable fibrinolysis inhibitor in type 2 diabetic patients. Hori, Y., Gabazza, E.C., Yano, Y., Katsuki, A., Suzuki, K., Adachi, Y., Sumida, Y. J. Clin. Endocrinol. Metab. (2002)
- Thrombin activatable fibrinolysis inhibitor (TAFI) levels in patients with coronary artery disease investigated by angiography. Schroeder, V., Chatterjee, T., Mehta, H., Windecker, S., Pham, T., Devantay, N., Meier, B., Kohler, H.P. Thromb. Haemost. (2002)
- Elevated Thrombin Activatable Fibrinolysis Inhibitor (TAFI) Antigen Levels in Overt and Subclinical Hypothyroid Patients Were Reduced by Levothyroxine Replacement. Akinci, B., Comlekci, A., Ali Ozcan, M., Demir, T., Yener, S., Demirkan, F., Yuksel, F., Yesil, S. Endocr. J. (2007)
- Simvastatin treatment improves endothelial function and increases fibrinolysis in patients with hypercholestrolemia. Guven, G.S., Atalar, E., Yavuz, B., Beyazit, Y., Kekilli, M., Kilicarslan, A., Sahiner, L., Oz, G., Ozer, N., Aksoyek, S., Haznedaroglu, I.C., Sozen, T. Journal of the National Medical Association. (2006)
- The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing. Cervoni, N., Detich, N., Seo, S.B., Chakravarti, D., Szyf, M. J. Biol. Chem. (2002)
- Regulation of adeno-associated virus DNA replication by the cellular TAF-I/set complex. Pegoraro, G., Marcello, A., Myers, M.P., Giacca, M. J. Virol. (2006)
- The histone chaperone SET/TAF-Ibeta interacts functionally with the CREB-binding protein. Karetsou, Z., Martic, G., Sflomos, G., Papamarcaki, T. Biochem. Biophys. Res. Commun. (2005)
- Aberrant intracellular localization of SET-CAN fusion protein, associated with a leukemia, disorganizes nuclear export. Saito, S., Miyaji-Yamaguchi, M., Nagata, K. Int. J. Cancer (2004)
- Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII. Vaesen, M., Barnikol-Watanabe, S., Götz, H., Awni, L.A., Cole, T., Zimmermann, B., Kratzin, H.D., Hilschmann, N. Biol. Chem. Hoppe-Seyler (1994)
- Inhibition of fibrinolysis by recombinant factor VIIa in plasma from patients with severe hemophilia A. Lisman, T., Mosnier, L.O., Lambert, T., Mauser-Bunschoten, E.P., Meijers, J.C., Nieuwenhuis, H.K., de Groot, P.G. Blood (2002)
- Sperm chromatin decondensation by template activating factor I through direct interaction with basic proteins. Matsumoto, K., Nagata, K., Miyaji-Yamaguchi, M., Kikuchi, A., Tsujimoto, M. Mol. Cell. Biol. (1999)
- Randomized trial of different regimens of heparins and in vivo thrombin generation in acute deep vein thrombosis. Kakkar, V.V., Hoppenstead, D.A., Fareed, J., Kadziola, Z., Scully, M., Nakov, R., Breddin, H.K. Blood (2002)
- Template activating factor I, a novel host factor required to stimulate the adenovirus core DNA replication. Matsumoto, K., Nagata, K., Ui, M., Hanaoka, F. J. Biol. Chem. (1993)
- Cellular localization and expression of template-activating factor I in different cell types. Nagata, K., Saito, S., Okuwaki, M., Kawase, H., Furuya, A., Kusano, A., Hanai, N., Okuda, A., Kikuchi, A. Exp. Cell Res. (1998)
- Functional interaction of the DNA-binding transcription factor Sp1 through its DNA-binding domain with the histone chaperone TAF-I. Suzuki, T., Muto, S., Miyamoto, S., Aizawa, K., Horikoshi, M., Nagai, R. J. Biol. Chem. (2003)
- Synergistic action of MLL, a TRX protein with template activating factor-I, a histone chaperone. Shimoyama, T., Kato, K., Miyaji-Yamaguchi, M., Nagata, K. FEBS Lett. (2005)
- The oncoprotein I-2PP2A/SET negatively regulates the MEK/ERK pathway and cell proliferation. Fukukawa, C., Shima, H., Tanuma, N., Okada, T., Kato, N., Adachi, Y., Kikuchi, K. Int. J. Oncol. (2005)
- I1PP2A and I2PP2A. Two potent protein phosphatase 2A-specific inhibitor proteins. Li, M., Damuni, Z. Methods Mol. Biol. (1998)
- A signaling role of histone-binding proteins and INHAT subunits pp32 and Set/TAF-Ibeta in integrating chromatin hypoacetylation and transcriptional repression. Kutney, S.N., Hong, R., Macfarlan, T., Chakravarti, D. J. Biol. Chem. (2004)
- Thanatos-associated protein 7 associates with template activating factor-Ibeta and inhibits histone acetylation to repress transcription. Macfarlan, T., Parker, J.B., Nagata, K., Chakravarti, D. Mol. Endocrinol. (2006)
- Thrombin activatable fibrinolysis inhibitor and the risk for deep vein thrombosis. van Tilburg, N.H., Rosendaal, F.R., Bertina, R.M. Blood (2000)
- Roles of thermal instability and proteolytic cleavage in regulation of activated thrombin-activable fibrinolysis inhibitor. Boffa, M.B., Bell, R., Stevens, W.K., Nesheim, M.E. J. Biol. Chem. (2000)