Disease relevance of ZFP91

• Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia [1].

High impact information on ZFP91

• However, the unexpected finding of zero flow during a prolonged diastole with a coronary artery pressure of 40 mmHg (PZF) is a reminder that the physical forces, including vascular smooth muscle contraction, that determine coronary vascular resistance are incompletely understood [2].
• Anti-sense oligonucleotides inhibited expression of ZFP91, suppressed cell growth, and induced apoptosis [1].
• Our results suggest that ZFP91 is likely to play an important role in cell proliferation and/or anti-apoptosis, and may serve as a molecular marker for AML [1].
• Its 92.5% identity in amino-acid sequence to the murine penta zinc finger protein (mPZf; gene symbol Zfp91), led us to term it ZFP91 [1].

References