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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GONST1  -  GDP-mannose transporter GONST1

Arabidopsis thaliana

Synonyms: T10F5.19, T10F5_19, golgi nucleotide sugar transporter 1
 
 
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High impact information on GONST1

  • GONST1 complemented a GDP-mannose transport-defective yeast mutant (vrg4-2), and Golgi-rich vesicles from the complemented strain displayed increased GDP-mannose transport activity [1].
  • We identified an Arabidopsis gene encoding a nucleotide sugar transporter (designated GONST1) that we have shown by transient gene expression to be localized to the Golgi [1].
  • Because of the differences in ability to rescue the vrg4 - 2 phenotype, and the different expression patterns in plant organs, we speculate that GONST1 and GONST2 are both GDP-mannose transporters, whereas GONST3, GONST4 and GONST5 may transport other nucleotide-sugars in planta [2].

References

  1. Identification and characterization of GONST1, a golgi-localized GDP-mannose transporter in Arabidopsis. Baldwin, T.C., Handford, M.G., Yuseff, M.I., Orellana, A., Dupree, P. Plant Cell (2001) [Pubmed]
  2. Arabidopsis thaliana expresses multiple Golgi-localised nucleotide-sugar transporters related to GONST1. Handford, M.G., Sicilia, F., Brandizzi, F., Chung, J.H., Dupree, P. Mol. Genet. Genomics (2004) [Pubmed]
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