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Gene Review:

PVRL4 - poliovirus receptor-related 4

Homo sapiens

Synonyms: EDSS1, Ig superfamily receptor LNIR, LNIR, Nectin-4, PRR4, ...

Fabre-Lafay, S. et al.

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Disease relevance of PVRL4

In vitro, a soluble form of Nectin-4 is produced in the supernatant of breast tumor cell lines (S. Fabre-Lafay, C. Ginestier, S. Garrido-Urbani, C. Berruyer, R. Sauvan, N. Reymond, J. Adelaide, J. Geneix, P. Dubreuil, J. Jacquemier, D. Birnbaum, and M. Lopez, manuscript in preparation) [1].

High impact information on PVRL4

Overexpression or small interfering RNA-mediated silencing of TACE enhanced or reduced Nectin-4 shedding, respectively [1].
We recently described Nectin-4, a 66-kDa adhesion molecule of the Nectin family, which is a valuable new histological and serological marker for breast carcinoma [1].
Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM-17 [1].
Nectin-4 is not shed when expressed in TACE-deficient fibroblasts [1].

Other interactions of PVRL4

Interestingly, the active form of TACE is overexpressed in breast tumors and may indicate that TACE is responsible for Nectin-4 shedding not only in vitro but also in vivo [1].

References

Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM-17. Fabre-Lafay, S., Garrido-Urbani, S., Reymond, N., Gonçalves, A., Dubreuil, P., Lopez, M. J. Biol. Chem. (2005) [Pubmed]

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