Gene Review:
PVRL1 - poliovirus receptor-related 1 (herpesvirus...
Homo sapiens
Synonyms:
CD111, CLPED1, ED4, HIgR, HV1S, ...
- Mutations of PVRL1, encoding a cell-cell adhesion molecule/herpesvirus receptor, in cleft lip/palate-ectodermal dysplasia. Suzuki, K., Hu, D., Bustos, T., Zlotogora, J., Richieri-Costa, A., Helms, J.A., Spritz, R.A. Nat. Genet. (2000)
- Restoration of E-cadherin-based cell-cell adhesion by overexpression of nectin in HSC-39 cells, a human signet ring cell gastric cancer cell line. Peng, Y.F., Mandai, K., Nakanishi, H., Ikeda, W., Asada, M., Momose, Y., Shibamoto, S., Yanagihara, K., Shiozaki, H., Monden, M., Takeichi, M., Takai, Y. Oncogene (2002)
- Requirement of interaction of nectin-1alpha/HveC with afadin for efficient cell-cell spread of herpes simplex virus type 1. Sakisaka, T., Taniguchi, T., Nakanishi, H., Takahashi, K., Miyahara, M., Ikeda, W., Yokoyama, S., Peng, Y.F., Yamanishi, K., Takai, Y. J. Virol. (2001)
- The ectodomain of a novel member of the immunoglobulin subfamily related to the poliovirus receptor has the attributes of a bona fide receptor for herpes simplex virus types 1 and 2 in human cells. Cocchi, F., Menotti, L., Mirandola, P., Lopez, M., Campadelli-Fiume, G. J. Virol. (1998)
- Mutation of PVRL1 is associated with sporadic, non-syndromic cleft lip/palate in northern Venezuela. Sözen, M.A., Suzuki, K., Tolarova, M.M., Bustos, T., Fernández Iglesias, J.E., Spritz, R.A. Nat. Genet. (2001)
- Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor. Geraghty, R.J., Krummenacher, C., Cohen, G.H., Eisenberg, R.J., Spear, P.G. Science (1998)
- Mutations in the N termini of herpes simplex virus type 1 and 2 gDs alter functional interactions with the entry/fusion receptors HVEM, nectin-2, and 3-O-sulfated heparan sulfate but not with nectin-1. Yoon, M., Zago, A., Shukla, D., Spear, P.G. J. Virol. (2003)
- Cellular localization of nectin-1 and glycoprotein D during herpes simplex virus infection. Krummenacher, C., Baribaud, I., Eisenberg, R.J., Cohen, G.H. J. Virol. (2003)
- The poliovirus receptor CD155 mediates cell-to-matrix contacts by specifically binding to vitronectin. Lange, R., Peng, X., Wimmer, E., Lipp, M., Bernhardt, G. Virology (2001)
- Regulation of E-cadherin endocytosis by nectin through afadin, Rap1, and p120ctn. Hoshino, T., Sakisaka, T., Baba, T., Yamada, T., Kimura, T., Takai, Y. J. Biol. Chem. (2005)
- PVRL1 variants contribute to non-syndromic cleft lip and palate in multiple populations. Avila, J.R., Jezewski, P.A., Vieira, A.R., Orioli, I.M., Castilla, E.E., Christensen, K., Daack-Hirsch, S., Romitti, P.A., Murray, J.C. Am. J. Med. Genet. A (2006)
- Mutation analysis of CLPTM 1 and PVRL 1 genes in patients with non-syndromic clefts of lip, alveolus and palate. Turhani, D., Item, C.B., Watzinger, E., Sinko, K., Watzinger, F., Lauer, G., Ewers, R. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. (2005)
- Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes. Kakunaga, S., Ikeda, W., Itoh, S., Deguchi-Tawarada, M., Ohtsuka, T., Mizoguchi, A., Takai, Y. J. Cell. Sci. (2005)
- Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin. Reymond, N., Borg, J.P., Lecocq, E., Adelaide, J., Campadelli-Fiume, G., Dubreuil, P., Lopez, M. Gene (2000)
- Nectin-1/HveC Mediates herpes simplex virus type 1 entry into primary human sensory neurons and fibroblasts. Simpson, S.A., Manchak, M.D., Hager, E.J., Krummenacher, C., Whitbeck, J.C., Levin, M.J., Freed, C.R., Wilcox, C.L., Cohen, G.H., Eisenberg, R.J., Pizer, L.I. J. Neurovirol. (2005)
- Mutations in herpes simplex virus glycoprotein D that prevent cell entry via nectins and alter cell tropism. Manoj, S., Jogger, C.R., Myscofski, D., Yoon, M., Spear, P.G. Proc. Natl. Acad. Sci. U.S.A. (2004)
- The V domain of herpesvirus Ig-like receptor (HIgR) contains a major functional region in herpes simplex virus-1 entry into cells and interacts physically with the viral glycoprotein D. Cocchi, F., Lopez, M., Menotti, L., Aoubala, M., Dubreuil, P., Campadelli-Fiume, G. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Specific association of glycoprotein B with lipid rafts during herpes simplex virus entry. Bender, F.C., Whitbeck, J.C., Ponce de Leon, M., Lou, H., Eisenberg, R.J., Cohen, G.H. J. Virol. (2003)
- Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry. Krummenacher, C., Nicola, A.V., Whitbeck, J.C., Lou, H., Hou, W., Lambris, J.D., Geraghty, R.J., Spear, P.G., Cohen, G.H., Eisenberg, R.J. J. Virol. (1998)
- Mutations in the N-terminal domains of nectin-1 and nectin-2 reveal differences in requirements for entry of various alphaherpesviruses and for nectin-nectin interactions. Struyf, F., Martinez, W.M., Spear, P.G. J. Virol. (2002)
- Disruption of adherens junctions liberates nectin-1 to serve as receptor for herpes simplex virus and pseudorabies virus entry. Yoon, M., Spear, P.G. J. Virol. (2002)
- Role of each immunoglobulin-like loop of nectin for its cell-cell adhesion activity. Yasumi, M., Shimizu, K., Honda, T., Takeuchi, M., Takai, Y. Biochem. Biophys. Res. Commun. (2003)
- Functional characterization of human CD34+ cells that express low or high levels of the membrane antigen CD111 (nectin 1). Belaaloui, G., Imbert, A.M., Bardin, F., Tonnelle, C., Dubreuil, P., Lopez, M., Chabannon, C. Leukemia (2003)
- Use of chimeric nectin-1(HveC)-related receptors to demonstrate that ability to bind alphaherpesvirus gD is not necessarily sufficient for viral entry. Geraghty, R.J., Fridberg, A., Krummenacher, C., Cohen, G.H., Eisenberg, R.J., Spear, P.G. Virology (2001)
- Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM-17. Fabre-Lafay, S., Garrido-Urbani, S., Reymond, N., Gonçalves, A., Dubreuil, P., Lopez, M. J. Biol. Chem. (2005)
- Nectin-1 Expression by Squamous Cell Carcinoma is a Predictor of Herpes Oncolytic Sensitivity. Yu, Z., Adusumilli, P.S., Eisenberg, D.P., Darr, E., Ghossein, R.A., Li, S., Liu, S., Singh, B., Shah, J.P., Fong, Y., Wong, R.J. Mol. Ther. (2007)