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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SHARPIN  -  SHANK-associated RH domain interactor

Homo sapiens

Synonyms: DKFZP434N1923, PSEC0216, SIPL1, Shank-associated RH domain-interacting protein, Shank-interacting protein-like 1, ...
 
 
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High impact information on SHARPIN

  • We have identified a novel protein, termed Sharpin, that directly interacts with the ankyrin repeats of Shank [1].
  • Considering the fact that the ankyrin repeats and the SH3 domain of Shank can be truncated by alternative splicing, these results define Sharpin as a novel PSD protein that may regulate the complexity of the Shank-based protein network in an alternative splicing-dependent manner [1].
  • The upregulation of SIPL1 in the fundus of W/WV mice, and expression in the upper gastrointestinal tract suggest that the SIPL1 gene could be associated with ICC function in mice and humans [2].
  • CONCLUSIONS: Gene analysis showed that SIPL1 differentially express in the gastric fundus of normal and W/WV mice [2].
  • SIPL1 was abundantly expressed in human stomach and small intestine, and scarcely expressed in cecum and rectum [2].

References

  1. Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins. Lim, S., Sala, C., Yoon, J., Park, S., Kuroda, S., Sheng, M., Kim, E. Mol. Cell. Neurosci. (2001) [Pubmed]
  2. Novel human and mouse genes encoding a shank-interacting protein and its upregulation in gastric fundus of W/WV mouse. Daigo, Y., Takayama, I., Ward, S.M., Sanders, K.M., Fujino, M.A. J. Gastroenterol. Hepatol. (2003) [Pubmed]
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