High impact information on CAD4

• AtCAD5 used all five substrates effectively, whereas AtCAD4 (of lower overall catalytic capacity) poorly used sinapyl aldehyde; the corresponding 270-fold decrease in k(enz) resulted from higher K(m) and lower k(cat) values, respectively [1].
• Functional reclassification of the putative cinnamyl alcohol dehydrogenase multigene family in Arabidopsis [1].
• Genomic nucleotide sequence of an Arabidopsis thaliana gene encoding a cinnamyl alcohol dehydrogenase [2].
• Crystal structures and catalytic mechanism of the Arabidopsis cinnamyl alcohol dehydrogenases AtCAD5 and AtCAD4 [3].
• In this study, we determined the crystal structures of AtCAD5 in the apo-form and as a binary complex with NADP(+), respectively, and modeled that of AtCAD4 [3].

Associations of CAD4 with chemical compounds

• The cinnamyl alcohol dehydrogenase (CAD) multigene family in planta encodes proteins catalyzing the reductions of various phenylpropenyl aldehyde derivatives in a substrate versatile manner, and whose metabolic products are the precursors of structural lignins, health-related lignans, and various other metabolites [3].

References