The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Sinapaldehyde     (E)-3-(4-hydroxy-3,5- dimethoxy-phenyl)prop...

Synonyms: AC1NQXM5, CHEMBL225067, CHEBI:27949, bmse000606, bmse010085, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Sinapoyl aldehyde


High impact information on Sinapoyl aldehyde

  • The active site topology revealed by the crystal structure substantiates kinetic results indicating that SAD maintains highest specificity for the substrate sinapaldehyde [2].
  • These data indicate that REF1 encodes a sinapaldehyde dehydrogenase required for sinapic acid and sinapate ester biosynthesis [3].
  • Cinnamyl alcohol dehydrogenase (CAD; EC has been thought to mediate the reduction of both coniferaldehyde and sinapaldehyde into guaiacyl and syringyl monolignols in angiosperms [4].
  • Liquid chromatography-mass spectrometry-based enzyme functional analysis and substrate level-controlled enzyme kinetics consistently demonstrated that PtSAD is sinapaldehyde specific and that PtCAD is coniferaldehyde specific [4].
  • AtCAD5 used all five substrates effectively, whereas AtCAD4 (of lower overall catalytic capacity) poorly used sinapyl aldehyde; the corresponding 270-fold decrease in k(enz) resulted from higher K(m) and lower k(cat) values, respectively [5].

Chemical compound and disease context of Sinapoyl aldehyde


Anatomical context of Sinapoyl aldehyde


Associations of Sinapoyl aldehyde with other chemical compounds


Gene context of Sinapoyl aldehyde

  • Consistent with this finding, extracts of ref1 leaves exhibit low sinapaldehyde dehydrogenase activity [3].


  1. Coniferyl aldehyde 5-hydroxylation and methylation direct syringyl lignin biosynthesis in angiosperms. Osakabe, K., Tsao, C.C., Li, L., Popko, J.L., Umezawa, T., Carraway, D.T., Smeltzer, R.H., Joshi, C.P., Chiang, V.L. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Structural and kinetic basis for substrate selectivity in Populus tremuloides sinapyl alcohol dehydrogenase. Bomati, E.K., Noel, J.P. Plant Cell (2005) [Pubmed]
  3. The Arabidopsis thaliana REDUCED EPIDERMAL FLUORESCENCE1 gene encodes an aldehyde dehydrogenase involved in ferulic acid and sinapic acid biosynthesis. Nair, R.B., Bastress, K.L., Ruegger, M.O., Denault, J.W., Chapple, C. Plant Cell (2004) [Pubmed]
  4. The last step of syringyl monolignol biosynthesis in angiosperms is regulated by a novel gene encoding sinapyl alcohol dehydrogenase. Li, L., Cheng, X.F., Leshkevich, J., Umezawa, T., Harding, S.A., Chiang, V.L. Plant Cell (2001) [Pubmed]
  5. Functional reclassification of the putative cinnamyl alcohol dehydrogenase multigene family in Arabidopsis. Kim, S.J., Kim, M.R., Bedgar, D.L., Moinuddin, S.G., Cardenas, C.L., Davin, L.B., Kang, C., Lewis, N.G. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  6. GOLD HULL AND INTERNODE2 encodes a primarily multifunctional cinnamyl-alcohol dehydrogenase in rice. Zhang, K., Qian, Q., Huang, Z., Wang, Y., Li, M., Hong, L., Zeng, D., Gu, M., Chu, C., Cheng, Z. Plant Physiol. (2006) [Pubmed]
  7. Pharmacologically active phenylpropanoids from Senra incana. Farah, M.H., Samuelsson, G. Planta Med. (1992) [Pubmed]
  8. Analysis of aromatic aldehydes in brandy and wine by high-performance capillary electrophoresis. Panossian, A., Mamikonyan, G., Torosyan, M., Gabrielyan, E., Mkhitaryan, S. Anal. Chem. (2001) [Pubmed]
  9. Initial steps of the peroxidase-catalyzed polymerization of coniferyl alcohol and/or sinapyl aldehyde: capillary zone electrophoresis study of pH effect. Fournand, D., Cathala, B., Lapierre, C. Phytochemistry (2003) [Pubmed]
WikiGenes - Universities