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Gene Review

AT4G31150  -  endonuclease V family protein

Arabidopsis thaliana

Synonyms: F6E21.70, F6E21_70
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High impact information on AT4G31150

  • ROS1 encodes an endonuclease III domain nuclear protein with bifunctional DNA glycosylase/lyase activity against methylated but not unmethylated DNA [1].
  • Analysis of cosmid N9 sequences identified a gene showing strong similarity to two homologous repair genes, RAD2 (Saccharomyces cerevisiae) and XPG (human), which encode an endonuclease required for nucleotide excision repair of UV-damage [2].


  1. ROS1, a repressor of transcriptional gene silencing in Arabidopsis, encodes a DNA glycosylase/lyase. Gong, Z., Morales-Ruiz, T., Ariza, R.R., Roldán-Arjona, T., David, L., Zhu, J.K. Cell (2002) [Pubmed]
  2. Arabidopsis UVH3 gene is a homolog of the Saccharomyces cerevisiae RAD2 and human XPG DNA repair genes. Liu, Z., Hall, J.D., Mount, D.W. Plant J. (2001) [Pubmed]
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