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Gene Review:

Glis2 - GLIS family zinc finger 2

Mus musculus

Synonyms: GLI-similar 2, Gli5, Klf16, Neuronal Krueppel-like protein, Nkl, ...

Zhang, F. et al., Kim, S.C. et al.

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High impact information on Glis2

Fluorescence in situ hybridization mapped the mouse Glis2 gene to chromosome 16A3-B1 [1].
Analysis of the genomic structure of the Glis2 gene showed that it is composed of 6 exons separated by 5 introns spanning a genomic region of more than 7.5 kb [1].
Characterization of Glis2, a novel gene encoding a Gli-related, Krüppel-like transcription factor with transactivation and repressor functions. Roles in kidney development and neurogenesis [1].
C-terminal binding protein 1 (CtBP1) was identified as one of the proteins that interact with Glis2 [2].
CtBP1 did not interact with other members of the Glis subfamily suggesting that this interaction is specific for Glis2 [2].

Other interactions of Glis2

Confocal microscopic analysis demonstrated that Glis2 localized to nuclear speckles while in most cells CtBP1 was found diffusely in both cytoplasm and nucleus [2].

Analytical, diagnostic and therapeutic context of Glis2

Northern blot analysis showed that the Glis2 gene encodes a 3.8-kb transcript that is most abundant in adult mouse kidney [1].

References

Characterization of Glis2, a novel gene encoding a Gli-related, Krüppel-like transcription factor with transactivation and repressor functions. Roles in kidney development and neurogenesis. Zhang, F., Nakanishi, G., Kurebayashi, S., Yoshino, K., Perantoni, A., Kim, Y.S., Jetten, A.M. J. Biol. Chem. (2002) [Pubmed]
Krüppel-like zinc finger protein Gli-similar 2 (Glis2) represses transcription through interaction with C-terminal binding protein 1 (CtBP1). Kim, S.C., Kim, Y.S., Jetten, A.M. Nucleic Acids Res. (2005) [Pubmed]

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