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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NUDT12  -  nudix (nucleoside diphosphate linked...

Homo sapiens

Synonyms: DKFZP761I172, Nucleoside diphosphate-linked moiety X motif 12, Nudix motif 12, Peroxisomal NADH pyrophosphatase NUDT12
 
 
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Disease relevance of NUDT12

  • The human NUDT12 Nudix hydrolase has been expressed in insect cells from a baculovirus vector as a His-tagged recombinant protein [1].
 

High impact information on NUDT12

  • Thus, like other NADH diphosphatases of the Nudix family, NUDT12 has a marked substrate preference for the reduced nicotinamide nucleotides [1].
  • Expression of NUDT12 as a C-terminal fusion to green fluorescent protein revealed that it was targeted to peroxisomes by the C-terminal tripeptide PNL acting as a novel type 1 peroxisomal targeting signal [1].
  • NUDT12 may act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle [1].

References

  1. Mammalian NADH diphosphatases of the Nudix family: cloning and characterization of the human peroxisomal NUDT12 protein. Abdelraheim, S.R., Spiller, D.G., McLennan, A.G. Biochem. J. (2003) [Pubmed]
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