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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Gtf2a1  -  general transcription factor II A, 1

Mus musculus

Synonyms: 19kDa, 37kDa, 6330549H03Rik, AA536742, AA959775, ...
 
 
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Disease relevance of Gtf2a1

  • The recombinant proteins stably expressed in Escherichia coli cells were purified from culture supernatants in a single step using Ni(2+)-chelating chromatography producing soluble proteins of 34kDa (LiRecDT4) and 37kDa (LiRecDT5) [1].
  • In contrast, a substantial degree of protection was conferred by subcutaneous vaccination with BCG, suggesting that BCG antigens that are conserved in M. ulcerans, such as TB10.4, the 19kDa antigen, PstS3 and Hsp70, may be interesting to consider as subunit vaccines in future prospects [2].
 

High impact information on Gtf2a1

  • The 37kDa protein annexin 1 (Anx-1; lipocortin 1) is a glucocorticoid-regulated protein that has been implicated in the regulation of phagocytosis, cell signalling and proliferation, and postulated to be a mediator of glucocorticoids action in inflammation and in the control of anterior pituitary hormone release [3].
 

Analytical, diagnostic and therapeutic context of Gtf2a1

  • The size of the expressed protein was 37kDa as estimated by migration in 10% sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) [4].

References

  1. Two novel dermonecrotic toxins LiRecDT4 and LiRecDT5 from Brown spider (Loxosceles intermedia) venom: From cloning to functional characterization. da Silveira, R.B., Pigozzo, R.B., Chaim, O.M., Appel, M.H., Silva, D.T., Dreyfuss, J.L., Toma, L., Dietrich, C.P., Nader, H.B., Veiga, S.S., Gremski, W. Biochimie (2007) [Pubmed]
  2. Immunogenicity of Mycobacterium ulcerans Hsp65 and protective efficacy of a Mycobacterium leprae Hsp65-based DNA vaccine against Buruli ulcer. Coutanceau, E., Legras, P., Marsollier, L., Reysset, G., Cole, S.T., Demangel, C. Microbes Infect. (2006) [Pubmed]
  3. The annexin-1 knockout mouse: what it tells us about the inflammatory response. Roviezzo, F., Getting, S.J., Paul-Clark, M.J., Yona, S., Gavins, F.N., Perretti, M., Hannon, R., Croxtall, J.D., Buckingham, J.C., Flower, R.J. J. Physiol. Pharmacol. (2002) [Pubmed]
  4. Cloning and expression of an outer membrane protein ompTS of Aeromonas hydrophila and study of immunogenicity in fish. Khushiramani, R., Girisha, S.K., Karunasagar, I., Karunasagar, I. Protein Expr. Purif. (2007) [Pubmed]
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