Gene Review:
HYAL2 - hyaluronoglucosaminidase 2
Homo sapiens
Synonyms:
Hyal-2, Hyaluronidase-2, Hyaluronoglucosaminidase-2, LUCA2, LuCa-2, ...
Danilkovitch-Miagkova,
Wicklow,
Zhang,
Salo,
Jardin,
Cromi,
Kuzmin,
Natowicz,
Yoneno,
Ijuin,
Maingonnat,
Bolis,
Tilly,
Viola,
Wouters,
Duh,
Vigetti,
Courel,
Tanne,
Liu,
Miller,
Hendriks,
Doi,
Bertrand,
Miller,
Dentener,
Lerman,
Passi,
Ghezzi,
Bastard,
Triggs-Raine,
De Luca,
Karousou,
Angeloni,
Vernooy,
Ohno,
Raio,
- Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus. Danilkovitch-Miagkova, A., Duh, F.M., Kuzmin, I., Angeloni, D., Liu, S.L., Miller, A.D., Lerman, M.I. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation. Rai, S.K., Duh, F.M., Vigdorovich, V., Danilkovitch-Miagkova, A., Lerman, M.I., Miller, A.D. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Expression and characterization of a soluble, active form of the jaagsiekte sheep retrovirus receptor, Hyal2. Vigdorovich, V., Strong, R.K., Miller, A.D. J. Virol. (2005)
- Hyaluronidase gene profiling and role of hyal-1 overexpression in an orthotopic model of prostate cancer. Patel, S., Turner, P.R., Stubberfield, C., Barry, E., Rohlff, C.R., Stamps, A., McKenzie, E., Young, K., Tyson, K., Terrett, J., Box, G., Eccles, S., Page, M.J. Int. J. Cancer (2002)
- Gene transfer to respiratory epithelia with lentivirus pseudotyped with Jaagsiekte sheep retrovirus envelope glycoprotein. Sinn, P.L., Penisten, A.K., Burnight, E.R., Hickey, M.A., Williams, G., McCoy, D.M., Mallampalli, R.K., McCray, P.B. Hum. Gene Ther. (2005)
- Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX. Triggs-Raine, B., Salo, T.J., Zhang, H., Wicklow, B.A., Natowicz, M.R. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Monoclonal antibodies to human squamous cell carcinoma of the lung and their application to tumor diagnosis. Kyoizumi, S., Akiyama, M., Kouno, N., Kobuke, K., Hakoda, M., Jones, S.L., Yamakido, M. Cancer Res. (1985)
- CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion. Bourguignon, L.Y., Singleton, P.A., Diedrich, F., Stern, R., Gilad, E. J. Biol. Chem. (2004)
- Characterization of promoter elements of the human HYAL-2 gene. Chow, G., Knudson, W. J. Biol. Chem. (2005)
- Identification of Hyal2 as the cell-surface receptor for jaagsiekte sheep retrovirus and ovine nasal adenocarcinoma virus. Miller, A.D. Curr. Top. Microbiol. Immunol. (2003)
- HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity. Lepperdinger, G., Strobl, B., Kreil, G. J. Biol. Chem. (1998)
- Expression and activity of hyaluronidase in human periodontal ligament fibroblasts. Ohno, S., Ijuin, C., Doi, T., Yoneno, K., Tanne, K. J. Periodontol. (2002)
- Genetic deletions in sputum as diagnostic markers for early detection of stage I non-small cell lung cancer. Li, R., Todd, N.W., Qiu, Q., Fan, T., Zhao, R.Y., Rodgers, W.H., Fang, H.B., Katz, R.L., Stass, S.A., Jiang, F. Clin. Cancer Res. (2007)
- Envelope-induced cell transformation by ovine betaretroviruses. Alberti, A., Murgia, C., Liu, S.L., Mura, M., Cousens, C., Sharp, M., Miller, A.D., Palmarini, M. J. Virol. (2002)
- Association of RON tyrosine kinase with the Jaagsiekte sheep retrovirus envelope glycoprotein. Varela, M., Chow, Y.H., Sturkie, C., Murcia, P., Palmarini, M. Virology (2006)
- Ability of hyaluronidase 2 to degrade extracellular hyaluronan is not required for its function as a receptor for jaagsiekte sheep retrovirus. Vigdorovich, V., Miller, A.D., Strong, R.K. J. Virol. (2007)
- Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase. Strobl, B., Wechselberger, C., Beier, D.R., Lepperdinger, G. Genomics (1998)
- Enhanced levels of hyaluronan in lungs of patients with COPD: relationship with lung function and local inflammation. Dentener, M.A., Vernooy, J.H., Hendriks, S., Wouters, E.F. Thorax (2005)
- Expression of HYAL2 mRNA, hyaluronan and hyaluronidase in B-cell non-Hodgkin lymphoma: relationship with tumor aggressiveness. Bertrand, P., Courel, M.N., Maingonnat, C., Jardin, F., Tilly, H., Bastard, C. Int. J. Cancer (2005)
- Hyaluronan content of Wharton's jelly in healthy and Down syndrome fetuses. Raio, L., Cromi, A., Ghezzi, F., Passi, A., Karousou, E., Viola, M., Vigetti, D., De Luca, G., Bolis, P. Matrix Biol. (2005)