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Gene Review: 

Crot  -  carnitine O-octanoyltransferase

Rattus norvegicus

Synonyms: COT, Cot, Peroxisomal carnitine O-octanoyltransferase
 
 
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Disease relevance of Crot

  • 1. In a highly differentiated Morris hepatoma 5123D the fraction of repetitive, cytoplasmic poly(A)-containing RNA hybridizing with DNA to the Cot values below 10(2) mol X sec/l is present in a higher proportion than in normal rat liver [1].
 

High impact information on Crot

 

Analytical, diagnostic and therapeutic context of Crot

  • Long [greater than 1.5 kilobases (kb)] sequences can be separated from short (0.2-0.4 kb) sequences by exclusion chromatography after renaturation of 4-kb DNA fragments to a repetitive Cot and digestion with the single-strand-specific S1 nuclease [3].

References

  1. Comparison of cytoplasmic RNA species from rat liver and Morris hepatoma 5123D. Brysch, B., Chorazy, M. Acta Biochim. Pol. (1980) [Pubmed]
  2. Effect of rattlesnake venom (Crot alus viridis helleri) on bone marrow. Wingert, W.A., Pattabhiraman, T.R., Powers, D., Russell, F.E. Toxicon (1981) [Pubmed]
  3. Sequence relationship between long and short repetitive DNA of the rat: a preliminary report. Wu, J.R., Pearson, W.R., Posakony, J.W., Bonner, J. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
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