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Gene Review

TOM2A  -  tobamovirus multiplication 2A protein

Arabidopsis thaliana

Synonyms: F5D14.17, F5D14_17, tobamovirus multiplication 2A
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Disease relevance of TOM2A

  • The data presented here suggest that TOM2A is also an integral part of the tobamovirus replication complex [1].

High impact information on TOM2A

  • The split-ubiquitin assay demonstrated an interaction of TOM2A both with itself and with TOM1, an integral membrane protein of A.thaliana presumed to be an essential constituent of tobamovirus replication complex [1].
  • TOM2A encodes a 280 amino acid putative four-pass transmembrane protein with a C-terminal farnesylation signal, while TOM2B encodes a 122 amino acid basic protein [1].

Anatomical context of TOM2A

  • These observations suggest that the formation of tobamoviral RNA replication complex occurs on TOM1-containing membranes and is facilitated by TOM2A [2].


  1. Arabidopsis TOBAMOVIRUS MULTIPLICATION (TOM) 2 locus encodes a transmembrane protein that interacts with TOM1. Tsujimoto, Y., Numaga, T., Ohshima, K., Yano, M.A., Ohsawa, R., Goto, D.B., Naito, S., Ishikawa, M. EMBO J. (2003) [Pubmed]
  2. Subcellular localization of host and viral proteins associated with tobamovirus RNA replication. Hagiwara, Y., Komoda, K., Yamanaka, T., Tamai, A., Meshi, T., Funada, R., Tsuchiya, T., Naito, S., Ishikawa, M. EMBO J. (2003) [Pubmed]
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