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Gene Review

TOM1  -  tobamovirus multiplication protein 1

Arabidopsis thaliana

Synonyms: ATTOM1, F17L22.250, F17L22_250, tobamovirus multiplication 1
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Disease relevance of TOM1


High impact information on TOM1

  • These observations suggest that the formation of tobamoviral RNA replication complex occurs on TOM1-containing membranes and is facilitated by TOM2A [1].
  • Positional cloning showed that TOM3 was one of two TOM1-like genes in Arabidopsis [3].
  • In this report, we subjected one of the tom1 mutants (tom1-1) to another round of mutagenesis and isolated a new mutant which did not permit a detectable level of tobamovirus multiplication [3].
  • Involvement of THH1, an Arabidopsis thaliana homologue of the TOM1 gene, in tobamovirus multiplication [4].
  • The phenotype of the mutant, YS241, was controlled primarily by a single nuclear recessive mutation named tom2-1, which was distinct from tom1, a separate mutation which also affects TMV-Cg multiplication [5].

Biological context of TOM1


Other interactions of TOM1


  1. Subcellular localization of host and viral proteins associated with tobamovirus RNA replication. Hagiwara, Y., Komoda, K., Yamanaka, T., Tamai, A., Meshi, T., Funada, R., Tsuchiya, T., Naito, S., Ishikawa, M. EMBO J. (2003) [Pubmed]
  2. Effects of the tom1 mutation of Arabidopsis thaliana on the multiplication of tobacco mosaic virus RNA in protoplasts. Ishikawa, M., Naito, S., Ohno, T. J. Virol. (1993) [Pubmed]
  3. Complete inhibition of tobamovirus multiplication by simultaneous mutations in two homologous host genes. Yamanaka, T., Imai, T., Satoh, R., Kawashima, A., Takahashi, M., Tomita, K., Kubota, K., Meshi, T., Naito, S., Ishikawa, M. J. Virol. (2002) [Pubmed]
  4. Involvement of THH1, an Arabidopsis thaliana homologue of the TOM1 gene, in tobamovirus multiplication. Fujisaki, K., Ravelo, G.B., Naito, S., Ishikawa, M. J. Gen. Virol. (2006) [Pubmed]
  5. Isolation of a mutant of Arabidopsis thaliana carrying two simultaneous mutations affecting tobacco mosaic virus multiplication within a single cell. Ohshima, K., Taniyama, T., Yamanaka, T., Ishikawa, M., Naito, S. Virology (1998) [Pubmed]
  6. Tobamovirus-resistant tobacco generated by RNA interference directed against host genes. Asano, M., Satoh, R., Mochizuki, A., Tsuda, S., Yamanaka, T., Nishiguchi, M., Hirai, K., Meshi, T., Naito, S., Ishikawa, M. FEBS Lett. (2005) [Pubmed]
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