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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CHD6  -  chromodomain helicase DNA binding protein 6

Homo sapiens

Synonyms: ATP-dependent helicase CHD6, CHD-6, CHD5, Chromodomain-helicase-DNA-binding protein 6, FLJ22369, ...
 
 
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High impact information on CHD6

  • RNA interference-mediated knockdown of CHD6 reduced both the basal and tert-butylhydroquinone-inducible expression of NQO1, a prototypical Nrf2 target gene [1].
  • Identification of differentially transcribed genes in human lymphoblastoid cells irradiated with 0.5 Gy of gamma-ray and the involvement of low dose radiation inducible CHD6 gene in cell proliferation and radiosensitivity [2].
  • Radiation-increased expression of CHD6 was also found in A549 cells and HeLa cells [2].

References

  1. The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation. Nioi, P., Nguyen, T., Sherratt, P.J., Pickett, C.B. Mol. Cell. Biol. (2005) [Pubmed]
  2. Identification of differentially transcribed genes in human lymphoblastoid cells irradiated with 0.5 Gy of gamma-ray and the involvement of low dose radiation inducible CHD6 gene in cell proliferation and radiosensitivity. Wang, H.P., Long, X.H., Sun, Z.Z., Rigaud, O., Xu, Q.Z., Huang, Y.C., Sui, J.L., Bai, B., Zhou, P.K. Int. J. Radiat. Biol. (2006) [Pubmed]
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