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Gene Review:

TBC1D3F - TBC1 domain family, member 3F

Homo sapiens

Synonyms: TBC1 domain family member 3F, TBC1 domain family member 3G, TBC1D3, TBC1D3E, TBC1D3G

Hodzic, D. et al., Paulding, C.A. et al.

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High impact information on TBC1D3

USP32 is an ancient, highly conserved gene, whereas TBC1D3 is derived from a recent segmental duplication, which is absent in most other mammals and shows rapid amplification and dispersal through the primate lineage [1].
This hominoid-specific oncogene arose as recently as 21-33 million years ago, after proliferation of the TBC1D3 segmental duplication in the primate lineage [1].
TBC1D3 is a member of the TBC1 domain family of proteins that stimulates the intrinsic GTPase activity of RAB5A, an essential actor in early endosome trafficking [2].
Although the oncogenic mechanism of TBC1D3 has yet to be elucidated, the TBC1D3 locus (chromosome 17q12) is amplified in 15% of primary prostate tumors [2].

Biological context of TBC1D3

TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12 [2].

References

The Tre2 (USP6) oncogene is a hominoid-specific gene. Paulding, C.A., Ruvolo, M., Haber, D.A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12. Hodzic, D., Kong, C., Wainszelbaum, M.J., Charron, A.J., Su, X., Stahl, P.D. Genomics (2006) [Pubmed]

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