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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TRAF7  -  TNF receptor-associated factor 7, E3...

Homo sapiens

Synonyms: DKFZp586I021, E3 ubiquitin-protein ligase TRAF7, MGC7807, RFWD1, RING finger and WD repeat-containing protein 1, ...
 
 
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High impact information on TRAF7

  • CYLD in turn leads to the inhibition of TRAF6 and TRAF7 likely via a deubiquitination-dependent mechanism [1].
  • Depletion of TRAF7 by antisense RNA inhibited MEKK3-mediated AP1 and CHOP activation [2].
  • Moreover, overexpression of TRAF7 induced caspase-dependent apoptosis [2].
  • In this report, we identified a protein designated as TRAF7, which contains a RING finger domain and a zinc finger domain that are mostly conserved with those of TRAFs [2].
  • Additional analysis showed expansion of the deletion affecting the adjacent downstream-located genes RAB26 and TRAF7, as well as the great majority of CASKIN1 [3].

References

  1. The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7. Yoshida, H., Jono, H., Kai, H., Li, J.D. J. Biol. Chem. (2005) [Pubmed]
  2. TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. Xu, L.G., Li, L.Y., Shu, H.B. J. Biol. Chem. (2004) [Pubmed]
  3. Gross genomic rearrangement involving the TSC2-PKD1 contiguous deletion syndrome: characterization of the deletion event by quantitative polymerase chain reaction deletion assay. Boehm, D., Bacher, J., Neumann, H.P. Am. J. Kidney Dis. (2007) [Pubmed]
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