Gene Review:
JUN - jun proto-oncogene
Homo sapiens
Synonyms:
AP-1, AP1, Activator protein 1, Proto-oncogene c-Jun, Transcription factor AP-1, ...
Rajas,
Collins,
Naumann,
Lambert,
Meyer,
Vasilevskaya,
Collins,
Wehkamp,
Wehkamp-von Meissner,
Enders,
Saggar,
Schlee,
de la Hoya,
Bengmark,
Park,
Dauça,
Malaplate-Armand,
Ferrari,
Chandrasekharappa,
Visvikis,
Batt,
O'Dwyer,
Hooghe-Peters,
Castrillo,
Heppner,
Masson,
Marx,
Spiegel,
Wehkamp,
Schröder,
Sonnenborn,
Erdos,
Burns,
Rudel,
Fellermann,
Wieland,
Guru,
Delhase,
Becuwe,
Harder,
Agarwal,
Bartsch,
Nuding,
Stange,
- Immunohistochemical detection of RAS, JUN, FOS, and p53 oncoprotein expression in human colorectal adenomas and carcinomas. Magrisso, I.J., Richmond, R.E., Carter, J.H., Pross, C.B., Gilfillen, R.A., Carter, H.W. Lab. Invest. (1993)
- Coordinate activation of activator protein 1 and inflammatory cytokines in response to Neisseria gonorrhoeae epithelial cell contact involves stress response kinases. Naumann, M., Rudel, T., Wieland, B., Bartsch, C., Meyer, T.F. J. Exp. Med. (1998)
- Cyclooxygenase-2 inhibitor (SC-236) suppresses activator protein-1 through c-Jun NH2-terminal kinase. Wong, B.C., Jiang, X.H., Lin, M.C., Tu, S.P., Cui, J.T., Jiang, S.H., Wong, W.M., Yuen, M.F., Lam, S.K., Kung, H.F. Gastroenterology (2004)
- Effect of acute and chronic psychostimulant drugs on redox status, AP-1 activation and pro-enkephalin mRNA in the human astrocyte-like U373 MG cells. Malaplate-Armand, C., Becuwe, P., Ferrari, L., Masson, C., Dauça, M., Visvikis, S., Lambert, H., Batt, A.M. Neuropharmacology (2005)
- Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1. Schenk, H., Klein, M., Erdbrügger, W., Dröge, W., Schulze-Osthoff, K. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease. Rademakers, R., Sleegers, K., Theuns, J., Van den Broeck, M., Bel Kacem, S., Nilsson, L.G., Adolfsson, R., van Duijn, C.M., Van Broeckhoven, C., Cruts, M. Neurobiol. Aging (2005)
- Enhancement of AP-1 DNA-binding activity during amphetamine- and phencyclidine-mediated behaviour in rats. Milanovic, D., Pesic, V., Rakic, L., Kanazir, S., Ruzdijic, S. Neuropharmacology (2006)
- Transcription factors of the NFAT family: regulation and function. Rao, A., Luo, C., Hogan, P.G. Annu. Rev. Immunol. (1997)
- c-Jun and JunB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin. Szabowski, A., Maas-Szabowski, N., Andrecht, S., Kolbus, A., Schorpp-Kistner, M., Fusenig, N.E., Angel, P. Cell (2000)
- Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Agarwal, S.K., Guru, S.C., Heppner, C., Erdos, M.R., Collins, R.M., Park, S.Y., Saggar, S., Chandrasekharappa, S.C., Collins, F.S., Spiegel, A.M., Marx, S.J., Burns, A.L. Cell (1999)
- JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Dérijard, B., Hibi, M., Wu, I.H., Barrett, T., Su, B., Deng, T., Karin, M., Davis, R.J. Cell (1994)
- Effects of geldanamycin on signaling through activator-protein 1 in hypoxic HT29 human colon adenocarcinoma cells. Vasilevskaya, I.A., O'Dwyer, P.J. Cancer Res. (1999)
- FRA-1 expression level modulates regulation of activator protein-1 activity by estradiol in breast cancer cells. Philips, A., Teyssier, C., Galtier, F., Rivier-Covas, C., Rey, J.M., Rochefort, H., Chalbos, D. Mol. Endocrinol. (1998)
- NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium. Wehkamp, J., Harder, J., Wehkamp, K., Wehkamp-von Meissner, B., Schlee, M., Enders, C., Sonnenborn, U., Nuding, S., Bengmark, S., Fellermann, K., Schröder, J.M., Stange, E.F. Infect. Immun. (2004)
- alpha-Lipoic acid and N-acetyl cysteine prevent zinc deficiency-induced activation of NF-kappaB and AP-1 transcription factors in human neuroblastoma IMR-32 cells. Mackenzie, G.G., Zago, M.P., Erlejman, A.G., Aimo, L., Keen, C.L., Oteiza, P.I. Free Radic. Res. (2006)
- Quercetin glucuronide prevents VSMC hypertrophy by angiotensin II via the inhibition of JNK and AP-1 signaling pathway. Yoshizumi, M., Tsuchiya, K., Suzaki, Y., Kirima, K., Kyaw, M., Moon, J.H., Terao, J., Tamaki, T. Biochem. Biophys. Res. Commun. (2002)
- Phorbol ester-induced amino-terminal phosphorylation of human JUN but not JUNB regulates transcriptional activation. Franklin, C.C., Sanchez, V., Wagner, F., Woodgett, J.R., Kraft, A.S. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Theoretical proposal: allele dosage of MAP2K4/MKK4 could rationalize frequent 17p loss in diverse human cancers. Cunningham, S.C., Gallmeier, E., Hucl, T., Dezentje, D.A., Abdelmohsen, K., Gorospe, M., Kern, S.E. Cell Cycle (2006)
- Enhancement of MEK/ERK signaling promotes glucocorticoid resistance in CD4+ T cells. Tsitoura, D.C., Rothman, P.B. J. Clin. Invest. (2004)
- Induction of vascular endothelial growth factor by tumor necrosis factor alpha in human glioma cells. Possible roles of SP-1. Ryuto, M., Ono, M., Izumi, H., Yoshida, S., Weich, H.A., Kohno, K., Kuwano, M. J. Biol. Chem. (1996)
- Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes. Balasubramanian, S., Efimova, T., Eckert, R.L. J. Biol. Chem. (2002)
- Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in human skin fibroblasts. Quan, T., He, T., Voorhees, J.J., Fisher, G.J. J. Biol. Chem. (2005)
- Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation. Na, S.Y., Choi, J.E., Kim, H.J., Jhun, B.H., Lee, Y.C., Lee, J.W. J. Biol. Chem. (1999)
- Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway. Caelles, C., González-Sancho, J.M., Muñoz, A. Genes Dev. (1997)
- Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma. Adcock, I.M., Lane, S.J., Brown, C.R., Lee, T.H., Barnes, P.J. J. Exp. Med. (1995)
- Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter. Benkoussa, M., Brand, C., Delmotte, M.H., Formstecher, P., Lefebvre, P. Mol. Cell. Biol. (2002)
- Induction of the angiogenic modulator fibroblast growth factor-binding protein by epidermal growth factor is mediated through both MEK/ERK and p38 signal transduction pathways. Harris, V.K., Coticchia, C.M., Kagan, B.L., Ahmad, S., Wellstein, A., Riegel, A.T. J. Biol. Chem. (2000)
- Regulation of JNK by MKK-7 in fibroblast-like synoviocytes. Inoue, T., Hammaker, D., Boyle, D.L., Firestein, G.S. Arthritis Rheum. (2006)
- Receptor-interacting protein 140 binds c-Jun and inhibits estradiol-induced activator protein-1 activity by reversing glucocorticoid receptor-interacting protein 1 effect. Teyssier, C., Belguise, K., Galtier, F., Cavailles, V., Chalbos, D. Mol. Endocrinol. (2003)
- CREB binding protein is a coactivator for the androgen receptor and mediates cross-talk with AP-1. Frønsdal, K., Engedal, N., Slagsvold, T., Saatcioglu, F. J. Biol. Chem. (1998)
- AP-1 and Oct-1 transcription factors down-regulate the expression of the human PIT1/GHF1 gene. Delhase, M., Castrillo, J.L., de la Hoya, M., Rajas, F., Hooghe-Peters, E.L. J. Biol. Chem. (1996)
- Prolactin and estrogen enhance the activity of activating protein 1 in breast cancer cells: role of extracellularly regulated kinase 1/2-mediated signals to c-fos. Gutzman, J.H., Nikolai, S.E., Rugowski, D.E., Watters, J.J., Schuler, L.A. Mol. Endocrinol. (2005)
- Ras and mitogen-activated protein kinase kinase kinase-1 coregulate activator protein-1- and nuclear factor-kappaB-mediated gene expression in airway epithelial cells. Zhou, L., Tan, A., Iasvovskaia, S., Li, J., Lin, A., Hershenson, M.B. Am. J. Respir. Cell Mol. Biol. (2003)
- Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase. Hasselblatt, P., Rath, M., Komnenovic, V., Zatloukal, K., Wagner, E.F. Proc. Natl. Acad. Sci. U.S.A. (2007)
- c-Jun supports ribosomal RNA processing and nucleolar localization of RNA helicase DDX21. Holmström, T.H., Mialon, A., Kallio, M., Nymalm, Y., Mannermaa, L., Holm, T., Johansson, H., Black, E., Gillespie, D., Salminen, T.A., Langel, U., Valdez, B.C., Westermarck, J. J. Biol. Chem. (2008)
- Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. Hu, M.C., Qiu, W.R., Wang, X., Meyer, C.F., Tan, T.H. Genes Dev. (1996)
- HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation. Muthumani, K., Choo, A.Y., Hwang, D.S., Premkumar, A., Dayes, N.S., Harris, C., Green, D.R., Wadsworth, S.A., Siekierka, J.J., Weiner, D.B. Blood (2005)
- Transient stimulation of the c-Jun-NH2-terminal kinase/activator protein 1 pathway and inhibition of extracellular signal-regulated kinase are early effects in paclitaxel-mediated apoptosis in human B lymphoblasts. Amato, S.F., Swart, J.M., Berg, M., Wanebo, H.J., Mehta, S.R., Chiles, T.C. Cancer Res. (1998)
- Interactions between adenovirus E1A and members of the AP-1 family of cellular transcription factors. Maguire, K., Shi, X.P., Horikoshi, N., Rappaport, J., Rosenberg, M., Weinmann, R. Oncogene (1991)
- ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB. Yang, X., Chen, Y., Gabuzda, D. J. Biol. Chem. (1999)
- Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ. Mittelstadt, P.R., Ashwell, J.D. J. Biol. Chem. (2001)
- Global gene expression analysis of estrogen receptor transcription factor cross talk in breast cancer: identification of estrogen-induced/activator protein-1-dependent genes. DeNardo, D.G., Kim, H.T., Hilsenbeck, S., Cuba, V., Tsimelzon, A., Brown, P.H. Mol. Endocrinol. (2005)