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Gene Review:

SLC25A33 - solute carrier family 25 (pyrimidine...

Homo sapiens

Synonyms: BMSC-MCP, Bone marrow stromal cell mitochondrial carrier protein, HuBMSC-MCP, MGC4399, PNC1, ...

Jakobsen, H. et al., Verma, M.M. et al., O'Donnell, J.P. et al.

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Disease relevance of SLC25A33

All mice immunized i.n. with PNC-1 and LT mutants were protected against bacteremia and cleared the pneumococci from the lung 24 h after i.n. challenge; pneumococcal density correlated significantly with serum IgG antibody levels [1].

High impact information on SLC25A33

Through the amino acid sequence analysis of the formic acid treated peptide, the cationic isozyme has been shown to be identical in amino acid sequence to the cDNA clone PNC1 [2].
The solid dispersion capsule PNC1 showed significantly higher absorption and dissolution and consequently better bioavailability than the corresponding physical mixture capsule (PNC1A) in healthy human volunteers [3].

References

Intranasal immunization with pneumococcal polysaccharide conjugate vaccines with nontoxic mutants of Escherichia coli heat-labile enterotoxins as adjuvants protects mice against invasive pneumococcal infections. Jakobsen, H., Schulz, D., Pizza, M., Rappuoli, R., Jónsdóttir, I. Infect. Immun. (1999) [Pubmed]
Characterization of two forms of cationic peroxidase from cultured peanut cells. O'Donnell, J.P., Wan, L., van Huystee, R.B. Biochem. Cell Biol. (1992) [Pubmed]
Dissolution, bioavailability and ulcerogenic studies on piroxicam-nicotinamide solid dispersion formulations. Verma, M.M., Kumar, M.T., Balasubramaniam, J., Pandit, J.K. Bollettino chimico farmaceutico. (2003) [Pubmed]

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