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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

AC1O53DV     methanoic acid

Synonyms: hydroxyformaldehyde
 
 
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Disease relevance of formic acid

 

Psychiatry related information on formic acid

 

High impact information on formic acid

 

Chemical compound and disease context of formic acid

 

Biological context of formic acid

  • For the approximately 500 secretory cells of the glands, this means an hourly output of 10 ng of formic acid per cell, or about 5% of cell volume [21].
  • The alpha- and beta-subunits were separated by gel filtration in formic acid, and the sequence of the amino-terminal 10 amino acids of the beta-subunit coincided with that deduced from the nucleotide sequence data [22].
  • To investigate the structural requirements for recognition and response to ligands by the human estrogen receptor (hER), a series of point mutations were generated in the hormone binding domain (HBD) of the receptor using a limited formic acid treatment of its cDNA [23].
  • Ruthenium-catalyzed hydrogenation of carbon dioxide to formic acid was theoretically investigated with DFT and MP4(SDQ) methods, where a real catalyst, cis-Ru(H)2(PMe3)3, was employed in calculations and compared with a model catalyst, cis-Ru(H)2(PH3)3 [24].
  • Formic acid mapping suggested that much, if not all, of this phosphorylation is located between residues 257 and 285 [25].
 

Anatomical context of formic acid

  • Perinuclear inclusions formed in cultured cells by expanded polyQ can be completely dissolved in concentrated formic acid, but a soluble protein oligomer containing the expanded polyQ and released by the formic acid is not dissociated to monomer [6].
  • Results presented here indicate that HBsAg denatured by treatment with formic acid was captured by accessory cells and presented to the T cells much more efficiently than the native HBsAg [26].
  • The finding that beta-protein immunoreactivity in senile plaques, E-NFT and I-NFT is increased at different formic acid concentrations suggests that beta-protein in each location is in a different conformation [27].
  • By treatment with 90% formic acid before fixation, the original staining character of elastic tissue can be restored [28].
  • We studied the elastic skeleton of major cerebral arteries in rats, monkeys, and one human using scanning electron microscopy after hot formic acid extraction followed by freeze-drying [29].
 

Associations of formic acid with other chemical compounds

 

Gene context of formic acid

  • Here, we report that we used sandwich enzyme-linked immunoabsorbent assay to quantitate various Abeta species in the frontal cortex of AD brains homogenized in 70% formic acid [35].
  • Immunoblot analysis of MRP fragments generated by digestion with formic acid or trypsin suggested that the MAb QCRL-1 epitope was located in the region connecting the two halves of MRP [36].
  • ApoE was detected in the highly insoluble formic acid fraction of the transgenic pancreas by an immunoblot study [37].
  • To examine whether the negative effect of the acidic C-terminal domain is brought about by interactions with the basic part of HMGB1 (N-terminal region, HMG-box domain), intramolecular cross-linking in combination with formic acid cleavage of the protein was used [38].
  • The concentration of IGF-I secreted into the medium was estimated by radioimmunoassay after formic acid-acetone cryoextraction, and secreted IGFBPs were analysed by Western ligand blot and immunoblot; accumulation of IGF-I mRNA was analysed by Northern blot [39].
 

Analytical, diagnostic and therapeutic context of formic acid

References

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  22. Nucleotide sequence of the fadA gene. Primary structure of 3-ketoacyl-coenzyme A thiolase from Escherichia coli and the structural organization of the fadAB operon. Yang, S.Y., Yang, X.Y., Healy-Louie, G., Schulz, H., Elzinga, M. J. Biol. Chem. (1990) [Pubmed]
  23. Structure-function analysis of the hormone binding domain of the human estrogen receptor by region-specific mutagenesis and phenotypic screening in yeast. Wrenn, C.K., Katzenellenbogen, B.S. J. Biol. Chem. (1993) [Pubmed]
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