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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NIFK  -  nucleolar protein interacting with the FHA...

Homo sapiens

Synonyms: MKI67 FHA domain-interacting nucleolar phosphoprotein, MKI67IP, NOPP34, Nopp34, Nucleolar phosphoprotein Nopp34, ...
 
 
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High impact information on MKI67IP

  • In addition, a moiety of hNIFK was co-localized with pKi-67 at the peripheral region of mitotic chromosomes [1].
  • In a binding assay utilizing Xenopus egg extracts, it was found that the mitosis-specific environment and two threonine residues within this portion of hNIFK (Thr-234 and Thr-238) were crucial for the efficient interaction of hNIFK and Ki-FHA, suggesting that hNIFK interacts with Ki-FHA in a mitosis-specific and phosphorylation-dependent manner [1].
  • Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions [2].
 

Associations of MKI67IP with chemical compounds

  • The pThr site of hNIFK recognized by Ki67 FHA is pThr234-Pro235, a motif also recognized by the proline isomerase Pin1 [2].
 

Other interactions of MKI67IP

  • Using fragments of its binding partner hNIFK, we show that Ki67-hNIFK binding involves ca 44 residues without a pTXX(D/I/L) motif [2].

References

  1. A novel nucleolar protein, NIFK, interacts with the forkhead associated domain of Ki-67 antigen in mitosis. Takagi, M., Sueishi, M., Saiwaki, T., Kametaka, A., Yoneda, Y. J. Biol. Chem. (2001) [Pubmed]
  2. Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions. Li, H., Byeon, I.J., Ju, Y., Tsai, M.D. J. Mol. Biol. (2004) [Pubmed]
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